ABSTRACT
Nutritional anaemia is frequently observed in India. Prevalence of anaemia in Indian children is 59% (Hb<11gm/dl) but it’s higher among rural children. Iron deficiency is most common type nutritional deficiency anaemia in children. The nearest correlation of iron deficiency anemia (IDA) can be made with Pandu Roga in Ayurveda. The side effects of oral allopathic iron preparations are very common, therefore to get a better alternative, two Ayurvedic medicines, the Guda Haritaki and Punarnava Mandura, were subjected to a clinical trial among children suffering from IDA. Aim: Determine the role of Guda Haritaki and Punarnava Mandura in the management of Pandu roga w.s.r. to iron deficiency anaemia among children. Materials and Methods: The study was conducted on 35 children of IDA for a period of 6 weeks. Clinical features (Panduta, Daurbalya etc.) and hematological parameters (Hb gm %, sr. ferritin etc.) were documented before, during and after treatment. Statistical Analysis Used: Observations of the study were analyzed and findings were evaluated by using statistical methods Results: In the present study 58.82% improvement in Panduta was observed with Guda haritaki, 65% with Punarnava Mandura and 67 % when both drugs were given together. No adverse effect of the trial drug was observed during the study. Conclusions: The results suggest that Punarnava mandura along with Guda Haritaki is more effective in comparison to single use of either formulation in the management of IDA in children.
ABSTRACT
Background: The prevalence of anaemia in general and iron deficiency anaemia in particular is presently rising in the society. The primary objective of this study was to determine the prevalence of anaemia among school going children in rural and semi urban areas of Kangra district (Himachal Pradesh). Secondary objective was to identify the etiological and contributory factors in anaemia on the basis of Ayurvedic fundamentals. Methods: A population of 200 children studying in different schools of rural and semi urban areas of Kangra district Himachal Pradesh and IPD as well as OPD of department of Kaumarbhritya, R.G.G. P.G. Ayurvedic college and hospital Paprola were included in the survey. The data obtained from the survey was evaluated to assess the prevalence of anemia and its correlates. To fulfill the aims and objectives a specially prepared performa was designed and all details of the children were recorded in it. Results: The prevalence of anaemia was found to be 69% in school going children in rural areas of Kangra district, Himachal Pradesh. The major risk factors which were observed in present study were nutrition, socio-economic status, pica and dewormification. Conclusion: Anaemia is comparatively more common among children of semi urban and rural areas of Himachal Pradesh possible due to multiple factors like low socioeconomic status, menstruation and inadequate diet etc.
ABSTRACT
Norovirus, a member of calciviruses family is the leading cause of community-acquired and nosocomial acute gastroenteritis or inflammation of the stomach and intestine. This pathogenic virus is highly communicable and found in the stools and vomit of infected persons. The symptoms of infection include sudden vomiting, diarrhea, abdominal cramp, headache, low grade fever, nausea, chills, etc. This RNA virus spreads through contaminated foods or liquids, sharing norovirus loaded objects and contact with infection individual. There is neither a specific medicine nor vaccination available for norovirus infection. Some vaccines are under pre-clinical trials. However, the virus can be controlled by following good personal hygiene practices such as hand washing, eating properly washed fruits and vegetables, properly cooked foods, and cleaning of the area occupied by patient. Norovirus infection can be regulated through public awareness and dissemination of proper knowledge about this viral infection. The present review summarizes the biology of infections caused by norovirus and their control measures.
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Microorganisms have developed several physiological adaptations to survive within extreme ecological niches including environments contaminated with heavy metals, pesticides, polycyclic aromatic hydrocarbons, and nuclear wastes. Microorganisms in extreme habitat are potential source of “novel biomolecule(s)” such as whole microbial cells, extremozymes and extremolytes, significantly required for environmental, industrial, and red medical/pharmaceutical biotechnology. These novel biomolecule(s) are valuable resources and may help improve economic development. The scanty information about the factors governing the microbial growth within stressed environments is the major constraint in the recovery of novel biomolecule(s) from extreme habitats. Understanding the structure, metabolic capabilities, microbial physiology, and factors governing the composition and role of indigenous microorganism is the key to success of any study. In recent past the problems associated with classical cultivation techniques have been resolved by an emerging approach referred to as “metagenomics”. Metagenomic studies give an insight into details of the structure, metabolic and physiological capabilities of indigenous microbial communities. High-throughput sequencing technologies in conjunction with metagenomics has aided in the identification and characterization of novel culturable and uncultured microorganisms with unique capabilities. Metagenomic studies have been used for isolation and characterization of novel biomolecule(s) relevant for white, grey, and red biotechnologies. The major objective of this review is to discuss the applications of metagenomic approach for bioprospection of novel biomolecule(s) and environmental bioremediation.
ABSTRACT
One unknown impurity(Imp-II)during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-(propan-2-ylamino)ethyl]benzene-1,2-diol (Imp-Ⅱ)using the liquid chromatography–mass spectrophotometry(LC–MS)analysis.Imp-Ⅱ was isolated by semi-preparative liquid chromatography from the impurity-enriched reaction crude sample. Its proposed structure was confirmed by nuclear magnetic spectroscopy such as 1H, 13C,DEPT(1D NMR),HSQC(2D NMR) and infrared spectroscopy(IR),and retention time and purity with HPLC followed by the chemical synthesis. Due to less removable nature of Imp-II during the purification,the synthetic process was optimized proficiently to control the formation of Imp-II below to the limit<0.12% in the course of reaction.The new chemical route was developed for the preparation of this impurity in required quantity with purity to use as reference standard. The most probable mechanism for the formation of Imp-II was discussed in details.
ABSTRACT
Buerger's disease also called thromboangiitis obliterans (TAO), is widely recognized as a specific disease characterized by onset of distal extremity ischemic symptoms at early age in absence of an underlying proximal embolic source, trauma, autoimmune disease, diabetes, or hyperlipidemia.1The disease is far more prevalent in the middle, near, and far east regions than in North America.2 It occurs predominantly in men, but recent evidence indicates that the incidence rate in women is increasing.3Treatment of Buerger's disease is primarily medical.Surgical treatment in non responders to medical management including lumbar sympathectomy has been tried without promising result. Various orthopaedic procedures have been tested in various studies for the treatment of peripheral vascular diseases with variable successes.We have used Ilizarov surgery to distract and then compress to produce stimulus for angiogenesis.Vascular Endothelial Factor (VEGF) is an angiogenic factor which stimulates endothelial cell growth, angiogenesis and capillary permeability.4 In this study we have measured the clinical improvement parameters and VEGF level after ilizarov procedure in peripheral arterial vascular disease.
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We report the use of video laryngoscope for the exchange of orotracheal tube to nasotracheal tube needed for mandibular repair in a case of oromaxillofacial injury.
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BACKGROUND: The geriatric population in India is increasing, and so is the prevalence of cancer. We aimed to study the knowledge, attitude and practices of end-of-life care issues of terminally ill geriatric cancer patients in our region. METHODS: A pilot cross-sectional qualitative study using case studies, focus group discussions on providers and recipients of palliative care, an open-ended, interviewer administered questionnaire on specialist doctors and practitioners (50), geriatric cancer patients (20) and healthy family members of patients (30), was done in Lucknow, the capital of Uttar Pradesh, India. RESULTS: Only 14 physicians (28%) could enumerate more than 3 important technical elements of end-of-life care. Two physicians (4%) utilized palliative care services but none had received training themselves. The explanations and counselling provided by physicians were mostly inadequate, incomplete and did not fully satisfy the patients and their relatives. Of the cancer patients, 19 (95%) desired to use special services but were unaware of such facilities. There was only one charitable organization for needy geriatric cancer patients in Lucknow. No specific health scheme existed in the programme of the Government of Uttar Pradesh. CONCLUSION: The knowledge and practices of physicians and specialists were not up to the expectations and requirements of terminally ill cancer patients. Curriculum-based learning or organized teaching of end-of-life care issues was non-existent. Western countries have well-organized subspecialty facilities for end-of-life needs; such facilities are lacking in India. Capacity building for the care of terminally ill geriatric cancer patients is urgently required in north India.
Subject(s)
Aged , Aged, 80 and over , Clinical Competence , Female , Focus Groups , Geriatric Assessment , Health Care Surveys , Health Knowledge, Attitudes, Practice , Health Services Needs and Demand , Health Services for the Aged/organization & administration , Hospice Care/psychology , Humans , India , Male , Medical Futility , Middle Aged , Neoplasms/psychology , Palliative Care/psychology , Physician-Patient Relations , Pilot Projects , Professional-Family Relations , Terminal Care/methods , Truth DisclosureABSTRACT
Mitochondria play an important role in both the life and death of cells. The past 7-8 years have seen an intense surge in research devoted toward understanding the critical role of mitochondria in the regulation of cell death. Mitochondria have, next to their function in respiration, an important role in apoptotic signaling pathway. Apoptosis is a form of programmed cell death important in the development and tissue homeostasis of multicellular organisms. Apoptosis can be initiated by a wide array of stimuli, including multiple signaling pathways that, for the most part, converge at the mitochondria. Although classically considered the powerhouses of the cell, it is now understood that mitochondria are also "gatekeepers" that ultimately determine the fate of the cell. Malfunctioning at any level of the cell is eventually translated in the release of apoptogenic factors from the mitochondrial intermembrane space resulting in the organized demise of the cell. These mitochondrial factors may contribute to both caspase-dependent and caspase-independent processes in apoptotic cell death. In addition, several Bcl-2 family members and other upstream proteins also contribute to and regulate the apoptosis. In this review, we attempt to summarize our current view of the mechanism that leads to the influx and efflux of many proteins from/to mitochondria during apoptosis.