A Case Series Of Sarcomatoid Transitional Cell Carcinoma Of Renal Pelvis And Collecting Duct Carcinoma Of Kidney

Sarcomatoid transitional cell carcinoma (TCC) of the renal pelvis and collecting duct carcinoma (CDC) of the kidney are rare types of malignant renal tumors with aggressive behavior. Here, we report a case series of these tumors, in males of age 65 years and 72 years, respectively. In both the cases, the left kidney was affected and they underwent the left-sided radical nephroureterectomy. Histologically, sarcomatoid TCC showed two components with invasive TCC and areas with spindle cells and osteoclastic type of giant cells. The immunohistochemistry showed diffuse positivity for CK7 and negativity for CK20 and p63 in both the components. CDC showed tubule-papillary patterns with marked desmoplasia. The patients were disease free after a follow-up of 12 months and 2½ years, respectively, without any adjuvant therapy

A study of expression of estrogen and progesterone receptor, in atrophic, hyperplastic and malignant endometrial lesions, with emphasis on relationship with prognostic parameters.

Background: Aims of current study were to study the expression of estrogen receptor (ER) and progesterone receptor (PR) in atrophic, hyperplastic and malignant endometrial tissue, using immunohistochemical markers. Methods: The study includes 100 cases of endometrial tissues (25 cases each of atrophic and hyperplastic endometria and 50 cases of endometrial carcinomas). Results: In atrophic endometrial, 20 cases were ER and PR rich. 5 cases showed complete loss of hormone receptors (4 were type I and 1 type II). All the 25 cases of hyperplasias were ER and PR positive with varying H-score. The analysis of the hormone receptors in endometrial carcinomas, indicated that ER in 34 cases (68%) and of the PR in 38 cases (76%) were positive. Conclusions: Majority of the asymptomatic postmenopausal atrophic and hyperplastic endometria, expressed ER and PR. The value of the statistical significance was equal for atrophic vs. carcinomas and also hyperplastic vs. carcinomas. Positive ER PR expression was significantly associated with grade I-II and stage IB tumours. The correlation of immunohistochemical findings with histologic grade and clinical stage could help in predicting biologic behaviour and planning treatment in patients who are diagnosed as having these tumors.