ABSTRACT
Objectives: International guidelines recommend the use of long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease [COPD], but the usefulness of short-acting bronchodilator assist use for stable COPD remains uncertain. The purpose of the present study was to objectively demonstrate the effects of assist use of procaterol, a short-acting Beta[2]-agonist, on the respiratory mechanics of stable COPD patients treated with a long-acting
bronchodilator using forced oscillation technique [FOT] and conventional spirometry. We also confirmed the length of time for which procaterol assist could significantly improve the pulmonary function
Methods: We enrolled 28 outpatients with mild to severe COPD [Global Initiative for Obstructive Lung Disease stages I-III], who had used the same long-acting bronchodilator for longer than 3 months and who were in stable condition. All measures were performed using both FOT and spirometry sequentially from 15 min to 2 h after inhalation
Results: Compared to baseline, inhaled procaterol assist use modestly but significantly improved spirometric and FOT measurements within 2 h after inhalation. These significant effects continued for at least 2 h. Significant correlations were found between parameters measured by spirometry and those measured by FOT
Conclusions: Procaterol assist use modestly but significantly improved pulmonary function determined by spirometry and respiratory mechanics in patients with stable COPD treated with long-acting bronchodilators. Thus, inhaled procaterol has the potential for assist use for COPD