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Abstract Introduction Transition periods are integral parts of a person's life span, characterized by phases of life and shifts in activity before adapting to new situations. Objectives This study aims to understand the high potential characteristics of students with disabilities and evaluate the roles of school-based occupational therapists (SBOT) in assisting these students during transition periods. Method This study comprised 196 students and five SBOT. Research instruments included a characteristic checklist for potential learners and an in-depth interview methodology. The checklist, developed from related literature, consisted of three domains: physical and socio-emotional health, self-determination, and communication and academic performance. Students' performance levels were rated by teachers, with high potential characteristics being defined as achieving an average total score ≥2.0, without obtaining a zero in any checklist item. Results Most participants achieved full scores for high potential characteristics in the physical and socio-emotional health domain. Most SBOT provided direct, indirect, and integrated services using various service delivery models that were tailored to different types of disabilities. Conclusion This study provides fundamental information for SBOT and school professionals to foster high-potential characteristics in students with disabilities during transition periods. Suitable services in the domains of physical and socio-emotional health, self-determination, and communication and academic performance can enhance these high-potential characteristics.
Resumo Introdução O período de transição é parte natural da vida de uma pessoa. Pode ser classificado por fases da vida e mudança de atividade antes de entrar em novas situações. Objetivos Explorar características de alto potencial de alunos com deficiência e investigar os serviços de terapeutas ocupacionais escolares (SBOTs) para esses alunos durante os períodos de transição. Método Participaram 196 alunos e 5 SBOTs. Os instrumentos de pesquisa compreenderam o checklist característico dos potenciais aprendizes e uma entrevista em profundidade. A lista de verificação foi desenvolvida pela literatura relacionada e consistia em três domínios, incluindo saúde física e socioemocional, autodeterminação e comunicação e desempenho acadêmico. A pontuação do nível de desempenho dos alunos foi avaliada pelos professores. As características de alto potencial dos estudantes deste estudo significaram a obtenção de pontuação total média igual ou superior a 2,0, não tendo tido nenhum zero em qualquer item avaliado pelo checklist. Resultados A maioria dos participantes atingiu a pontuação completa das características de alto potencial no domínio saúde física e socioemocional. A maioria das SBOTs prestava serviços diretos, indiretos e integrados com base em diversos modelos de prestação de serviços diferenciados para cada tipo de deficiência. Conclusão Este estudo fornece informações fundamentais para SBOTs e profissionais escolares a fim de estimular características de alto potencial em alunos com deficiência em períodos de transição. Serviços adequados nas áreas de saúde física e socioemocional, autodeterminação e comunicação e desempenho acadêmico podem aprimorar características de alto potencial para esses estudantes.
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Objective To investigate the clinical application of multi-criteria optimization (MCO) in radiotherapy for cervical cancer. Methods A retrospective analysis was performed on the clinical data of 15 patients who received radiotherapy for cervical cancer in Shandong Cancer Hospital and Institute. A fixed field intensity-modulated radiotherapy plan was re-optimized using 9 fields on the Halcyon platform, with the goal of achieving a target coverage of > 95% and the lowest dose to organs at risk. The plan was refined until it reached the goal (Plan I) and was calculated using MCO to reach the goal (Plan MI), and the quality assurance verification was performed. The Wilcoxon rank-sum test was used to compare design time, target coverage, radiation dose to organs at risk, and number of monitor units between the plans. Results Both plans met the clinical requirements. There were no significant differences in target dose indices between Plan I and Plan MI (P > 0.05). Plan MI reduced the maximum dose to the small intestine by 0.51 Gy (P < 0.05). There was no significant difference in dose coverage between the bladder and the rectum (P > 0.05). Compared with Plan I, Plan MI saved 34.04 min in design time (P < 0.05). Conclusion MCO can improve the optimization and adjustment, significantly shorten the design time, and improve the efficiency of the plan.
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Objective The prevalence of nonalcoholic fatty liver disease(NAFLD) is increasing in middle-aged and older people. This article aimed to analyze the relationship between thyroid hormone and NAFLD in euthyroid middle-aged and older people.Methods We retrospectively analyzed 589 euthyroid patients aged 40 years or older who were hospitalized in our department from January 2015 to December 2017. According to the Results of abdominal ultrasound, they were divided into NAFLD group (n=217) and non-NAFLD group (n=372). We compared the differences of general data between two groups and analyzed the association of thyroid hormones(FT3, TSH) with metabolic indexes and the risk of NAFLD.Results TSH and FT3 in NAFLD group were significantly higher than those in non-NAFLD group (respectively 2.18±1.01 mIU/L versus 1.74±0.77 mIU/L, P<0.001; 4.54±0.72 pmol/L vs 4.05±0.83 pmol/L, P<0.001). After adjusting for age and sex, TSH was positively correlated with BMI, abdominal circumference, and LDL (r, P respectively were 0.117, 0.005; 0.136, 0.001; 0.086, 0.037). FT3 was positively correlated with LDL (r=0.098, P=0.017), and negatively correlated with FPG and HbA1c (r, P respectively were -0.161, <0.001; -0.139, 0.001). With the increase of TSH and FT3 quartiles, the risk of NAFLD showed a significantly increasing trend (P<0.01). Logistic regression analysis showed that abdominal circumference, BMI, ALT, TG, TSH, and FT3 were independent risk factors of NAFLD. Conclusion TSH and FT3 are risk factors of NAFLD in euthyroid middle-aged and older people, which can be used as a good serological indicator of NAFLD.
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From September to October 2018, a questionnaire survey was conducted on the status of diabetes management, basic equipment allocation, complication screening and follow-up, basic drug supply and health education among 136 grassroots institutions in Nanjing. Doctors in the 136 grassroots institutions who had received diabetes specialist training accounted for 18.2% (358/1 968) of total general practitioners. The management rate of diabetes patients was 98.67% (196 352/199 000) , and the standard management rate was 88.63%(174 024/196 352).The screening and follow-up rates of diabetic complications were 89.0%(121/136) and 61.2%(74/121) for glycosylated hemoglobin; 64.7%(88/136), 58.0%(51/88) for urine microalbumin;51.5% (70/136), 62.9%(44/70) for diabetic foot; 44.9%(61/136), 42.6%(26/61) carotid ultrasonography; 32.4%(44/136) and 59.1%(26/44) for fundus examination; 17.6%(24/136) and 33.3%(8/24) for ankle brachial index. The rates of screening for glycosylated hemoglobin, urinary microalbumin, diabetic foot, carotid B ultrasound, fundus and ankle brachial index in urban areas were significantly higher than those in the suburbs (both P<0.05). The diabetes health education was regularly conducted in 92.0%(126/136) of grassroots institutions. At present, the grassroots institutions in Nanjing have established health archives for most diabetic patients and conducted health education regularly, but the professional training and the screening of diabetic complications need to be strengthened.
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From September to October 2018,a questionnaire survey was conducted on the status of diabetes management,basic equipment allocation,complication screening and follow-up,basic drug supply and health education among 136 grassroots institutions in Nanjing.Doctors in the 136 grassroots institutions who had received diabetes specialist training accounted for 18.2％ (358/1 968) of total general practitioners.The management rate of diabetes patients was 98.67％(196 352/199 000),and the standard management rate was 88.63％(174 024/196 352).The screening and follow-up rates of diabetic complications were 89.0％(121/136) and 61.2％(74/121) for glycosylated hemoglobin;64.7％(88/136),58.0％(51/88) for urine microalbumin;51.5％ (70/136),62.9％(44/70) for diabetic foot;44.9％(61/136),42.6％(26/61) carotid ultrasonography;32.4％(44/136) and 59.1％(26/44) for fundus examination;17.6％(241136) and 33.3％(8/24) for ankle brachial index.The rates of screening for glycosylated hemoglobin,urinary microalbumin,diabetic foot,carotid B ultrasound,fundus and ankle brachial index in urban areas were significantly higher than those in the suburbs (both P＜0.05).The diabetes health education was regularly conducted in 92.0％(126/136) of grassroots institutions.At present,the grassroots institutions in Nanjing have established health archives for most diabetic patients and conducted health education regularly,but the professional training and the screening of diabetic complications need to be strengthened.
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Objective To explore the feasibility of using the optimization parameters modification and optimization processes modification to reduce the total monitor units ( MUs ) in the Eclipse radiotherapy treatment planning system (TPS). Methods Based on the radiotherapy plan of 10 patients with nasopharyngeal carcinoma, a total of 90 plans were designed for 9 groups using different optimization parameters and processes. The total MUs and the exposure dose of the organs among the different plans were compared. Results There was no significant difference in the doses of the organs at risk (class I) under the premise of target dose requirements (all P>0.05). The increase of the weight of the target area and the organs at risk will increase the total MUs. The increase of the preset limit value of the minimum MUs in the subfield will reduce the total MUs. The increase of the fluence smoothness in the X and Y directions will increase the total MUs. An unreasonable minimum MU value will increase the total MUs. Under the condition that the organ exposure is not changed significantly, the influencing factors of MU are ranked as weight>fluence smoothness>minimum MUs. Conclusions Parameter setting and process planning can reduce the total MUs to a certain extent. However, due to the complexity of the influence of optimization parameters on the plan, the optimization process should be preferred. Especially in the Eclipse TPS, the method of gradual optimization to achieve the final dose distribution requirement and then remove the fluence re-optimization is more convenient and effective for reducing the total MUs.
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Objective To detect the relaxation property of mesoporous silicananocapsules loaded liposomes (MSN-LIPO), and to explore their functions of enhancing MRI T2 weighted imaging. Methods In vitro, MSN-LIPO with different ironconcentrations were scanned by MRI system to detect their relaxation properties. In vivo, six BALB/c nude mouse models with subcutaneous malignant glioma were established and randomly divided into two groups, which were injected with the same concentration of MSN-LIPO intratumorally and intravenously, respectively. The mice in the two groups were scanned by MRI before and after injection, and the image characteristicswere studied and the signal intensity of tumors was statistically analyzed. Results In vitro MRI imaging showed that the signal intensities of the images were gradually decreased with the increase of iron concentrations in MSN-LIPO, and 1/T2 had a good linear relationship with the concentration within a certain range, with the relaxation rate (r2) being 413.7 mmoL-1 s-1. MRI imaging of BALB/ c nude mouse models with malignant glioma showed that the signal intensity of the tumor after intratumor injection of MSN-LIPO was significantly lower than that before intra-tumor injection (15.34±1.24 vs 211.44 ± 5.34, t=36.38, P < 05), and the signal intensity of the tumor after intravenous injection of MSN-LIPO was significantly lower than that before intravenous injection (179.00 ± 4.35 vs 235.99 ± 5.17, t=14.34, P <0.05). Conclusion MSN-LIPO has good magnetic relaxation property and good MRI T2 weighted contrast enhancement function in vivo, suggesting that it can be used as a MRI T2 contrast agent.
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Objective To prepare and characterize a thermo-sensitive liposomes co-loaded with IR-780 and doxorubicin (D0X). Methods Membrane hydration method and ammonium sulfate gradient method were used to prepare IR-780/D0X thermo-sensitive liposomes (DITSL). The particle size, zeta potential and polydispersity coefficient (PDI) of liposomes were measured by Malvern laser particle size analyzer, and the drug release characteristic of DITSL induced by laser was also detected. Results DITSL loading both IR-780 and D0X was successfully prepared. The encapsulation efficiency of IR-780 and D0X was (94.47 ± 8.57) % and (92.52 ± 7.61)%, respectively; the average particle size was (138.98 ± 8.74) nm, with slight negative potential; the PDI was 0.32 ± 0.02. The drug release rate of DITSL was about 80.1% after laser radiation (0. 8 W/cm2, 5 min) and the highest temperature of DITSL was 54.2°C. Conclusion The prepared DITSL has high drug encapsulation efficiency, appropriate particle size, high photo-thermal conversion efficiency, good temperature sensitivity and laser-induced thermal drug release property, which lays a foundation study for the combination treatment of tumors with photo-thermal therapy and chemotherapy.
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<p><b>BACKGROUND</b>During craniotomies using the transpetrosal-presigmoid approach, exposure of the sigmoid sinus remains an essential but hazardous step. In such procedures, accurate localization of the anterosuperior point of the transverse-sigmoid sinus junction (ASTS) is very important for reducing surgical morbidity. This study aimed to create an accurate and practical method for identifying the ASTS.</p><p><b>METHODS</b>On the lateral surfaces of 40 adult skulls (19 male skulls and 21 female skulls), a rectangular coordinate system was defined to measure the x and y coordinates of two points: the ASTS and the squamosal-parietomastoid suture junction (SP). With the coordinate system, the distribution characteristics of the ASTS were statistically analyzed and the differences between the ASTS and SP were investigated.</p><p><b>RESULTS</b>For ASTS-x, significant differences were found in different sides (P = 0.020); the ASTS-x in male skulls was significantly higher on the right side (P = 0.017); there was no significant difference between the sides in female skulls. There were no significant differences in gender or interaction of gender and side for ASTS-x, and for ASTS-y, there were no significant differences in side, gender, or interaction of gender and side. For both sides combined, the mean ASTS-x was significantly higher than the mean SP-x (P = 0.003) and the mean ASTS-y was significantly higher than the mean SP-y (P = 0.011).</p><p><b>CONCLUSIONS</b>This reference coordinate system may be an accurate and practical method for identifying the ASTS during presigmoid craniotomy. The SP might be difficult to find during presigmoid craniotomy and, therefore, it is not always a reliable landmark for defining the ASTS.</p>
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Adult , Female , Humans , Male , Middle Aged , Cranial Sinuses , Craniotomy , Skull , Transverse SinusesABSTRACT
Objective To explore the effectiveness of individual rehabilitation therapy in patients with nonspecific low back pain.Methods A total of 50 patients with nonspecific low back pain ( NLBP) between January 2013 and January 2015 were enrolled in this study.Individual rehabilitation therapy was performed based on their different pathogenesis and risk factor of low back pain.Visual analogue score (VAS),Oswestry disability index ( ODI) and Japanese orthopaedic association ( JOA) were used for the assessment of effectiveness of individual rehabilitation therapy.Results Compared with pre-rehabilitation, VAS and ODI scores were significantly decreased at two-week after rehabilitation(P<0.05),and were further decreased at six-week after rehabilitation(P<0.01).The mean score of JOA of 50 patients before rehabilitation was (10.83 ±2.94) score,which was decreased to (24.37±7.55 )score at six-week after rehabilitation(P<0.05),with 12 patients were cured,32 were improved obviously,6 were improved moderately.The rate of efficacy was 100%.Conclusion Individual rehabilitation therapy was an effective option for NLBP,with significant decrease of pain.
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Objective To evaluate and analyze the characteristics of cognitive and memory disorders in patients suffering cerebral infarction. Methods The scores of overall cognitive function including orientation to time and place, immediate memory, calculation, delayed memory, naming, repeat, understanding, reading, writing, visuospatial function were evaluated by mini-mental state estimate (MMSE) and the scores of memory function including immediate learning and memory , short time delayed recall , long time delay memories were evaluated by WHO/UCLA Auditory Verbal Learning Test. Statistical analysis were done in patients with cerebral infarction and healthy controls. Results The scores of overall cognitive function, memory scores as well as immediate recall , short-delayed recall , long-delayed recall in cerebral infarction patients were much lower than those of healthy controls (P < 0.001). Conclusion The overall cognitive function and memory function declined significantly , also immediate memory and short term memory were remarkable impaired in patients with cerebral infarction, resulting their memory characteristics were similar to patients with Alzheimer′s disease.
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The real sanghuang is a new species belonging to the Inonotus, which is commonly used for cancer treatment and human immune system improvement. This review summarized the progress on the studies of Phellinus Quel in recent years, including its taxonomy status, bioactive components, pharmacodynamics, separation and purification technologies. In addition, some related problems and perspectives were also discussed.
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Animals , Humans , Basidiomycota , Chemistry , Classification , Medicine, Chinese Traditional , MethodsABSTRACT
@# Objective To investigate the effects of intensive training for mimetic muscle on idiopathic facial paralysis. Methods 105 patients with idiopathic facial paralysis were divided into control group (n=53) and treatment group (n=52). All the patients received the routine treatment, including drugs, physical therapy, acupuncture and psychological support, while the treatment group was treated with intensive training for mimetic muscle in addition. Results 1 month after treatment, the muscle strength improved more in the treatment group than in the control group (P<0.01). The incidence of cure was 65.38% in the treatment group, more than 39.62% in the control group (P<0.01), as well the the total improvement of 96.15% and 83.02% respectively (P<0.05). Conclusion The intensive training for mimetic muscle can improve recovery of facial paralysis.
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Objective To investigate the effects of intensive training for mimetic muscle on idiopathic facial paralysis. Methods 105 pa-tients with idiopathic facial paralysis were divided into control group (n=53) and treatment group (n=52). All the patients received the rou-tine treatment, including drugs, physical therapy, acupuncture and psychological support, while the treatment group was treated with inten-sive training for mimetic muscle in addition. Results 1 month after treatment, the muscle strength improved more in the treatment group than in the control group (P<0.01). The incidence of cure was 65.38%in the treatment group, more than 39.62%in the control group (P<0.01), as well the the total improvement of 96.15%and 83.02%respectively (P<0.05). Conclusion The intensive training for mimetic mus-cle can improve recovery of facial paralysis.
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ObjectiveTo establish rat model of traumatic brain injury combined with hemorrhagic shock.Methods Rat models of traumatic brain injury (produced by free fall impact method) combined with hemorrhagic shock (produced by venous injury method) were established and the related physiological parameters were recorded.The neurological impairment score,cerebral edema degree and blood brain barrier (BBB) were determined by using neurofunction scales,dry-wet method and Evans blue (EB) respectively.HE staining and immunohistochemical staining were applied to evaluate the pathological changes in brain sections.ResultsBlood pressure dropped from 95 mm Hg to 25 mm Hg within three minutes after modeling and maintained around 60 mm Hg one hour later.Neurological impairment score was increased dramatically.The ratio of water content in the brain tissue was elevated nearly from 77％ to 81％.The concentration of EB residual in the brain tissue was increased more than one fold.Neuronal pathological abnormalities,including neuron shrinking,dark eosinophilic staining,perineuronal vacuole in HE staining,and positive staining of β-amyloid precursor protein (β-APP) in immunohistochemical staining were also observed. ConclusionsRat models of traumatic brain injury combined with hemorrhagic shock are successfully established.In addition,the main pathological changes,such as cerebral edema,disruption of BBB,neuron damage,and expression of β-APP are replicated.
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@# ObjectiveTo observe the effects of different environmental intervention on neurofilament (NF) expression in rats after unilateral local cerebral infarction. MethodsAfter middle cerebral artery occluded (MCAO) by electric coagulation, 125 male SD rats were randomly divided into individual living group (n=30, living alone in small standard cages), social communication group (n=30, 5 as a group living in large standard stages ), learning group(n=30, 15 as a group living in exploratory cages), enriched environment group (n=30, 5 as a group living in EE cages) and sham operated group(n=5). The rats were randomly sacrificed at the 1st, 3rd, 7th, 14th, 21st, 28th day after MCAO. The expressions of NF in peri-ischemic cortex were detected with immunohistochemistry staining. ResultsThe expression of NF in the peri-ischemia cortex in enriched environment group and learning group was higher than that in other two groups (P<0.01) after 7 days, it also was higher in social communication group than that in individual living group (P<0.05). ConclusionEnriched environment and learning could enhance NF expression in rats after unilateral local cerebral infarction.
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Objective To observe the effects of statins on ATP-binding cassette transporter 1(ABCA1) gene expression in neurons and astrocytes.Methods Primary human astrocytes and neuron cell line HCN-2 were incubated with simvastatin and pravastatin at different concentrations and under different conditions.Using RNA isolated from the cultured cells,we performed quantitative PCR to measure the ABCA1 gene expression in astrocytes and neurons.The protein expression of ABCA1 was measured by Western blot.Results The two statins significantly decreased the ABCA1 gene and protein expressions.Compared with pravastatin,simvastatin significantly reduced the expression of ABCA1 in neurons and astrocytes by 95% and 75%,respectively(both P