ABSTRACT
Background: Depression is a common co-morbidity among persons living with human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) (PLWHAs). It is associated with poor treatment adherence and higher mortality rates. Few reports have; however; emanated from developing countries where socioeconomic factors may confound this association. Materials and Methods: We conducted a cross-sectional comparative study of PLWHAs and apparently healthy staff of three LGA's. The depression module of the Schedule for the Clinical Assessment in Neuropsychiatry (SCAN) and the Beck Depression Inventory (BDI) was used to diagnose depression and depression symptom severity; respectively. Results: Depression was commonly co-morbid among individuals with HIV/AIDS. It was five times more common in PLWHAs than in apparently healthy populations (29.3vs. 7.3; OR: 5.25; 95 CI: 2.50-11.76). A similar trend was observed for depression symptom severity. Among PLWHAs; depression was significantly more likely among females (OR: 7.91; 95 CI: 1.83-71.00; P 0.01); those unemployed (OR: 2.94; 95CI: 0.18-1.82; P 0.04); and with an illness duration 3 years (OR: 7.90; P 0.0001). Having at least one child (OR: 2.79; 95 CI: 1.25-6.16; P 0.001) and living with others (OR: 4.71; 95 CI: 1.51-15.52; P 0.003) significantly reduced depression risk. Conclusion: Depression was commonly co-morbid among PLWHAs studied. Clinicians should be aware of risk factors for depression among PLWHAs in order to improve treatment outcomes