ABSTRACT
Dysgerminoma developed in a 21-year-old phenotypic female patient with 46,XY pure gonadal dysgenesis, Swyer syndrome. This patient presented with pelvic mass associated with abdominal pain and primay amenorrhea. Clinical characteristics showed a typical stigmata of gonadal dysgenesis: primary amenorrhea, sexual infantilism, a small uterus and left streak gonad. A 46,XY karyotype was made by lymphocyte culture. The patient was counseled to undergo operation, chemotherapy and hormon therapy. She underwent bilateral gonadectomy with total hysterectomy, partial omentectomy and multiple pelvic wall random biopsy. Histological examination revealed dysgenetic gonads with dysgerminoma. After surgery, the patient received chemotherapy and also was started on hormone replacement therapy. She is currently alive with no evidence of disease after 19 months from surgery.
Subject(s)
Female , Humans , Young Adult , Abdominal Pain , Amenorrhea , Biopsy , Christianity , Drug Therapy , Dysgerminoma , Gonadal Dysgenesis , Gonadal Dysgenesis, 46,XY , Gonads , Hormone Replacement Therapy , Hysterectomy , Karyotype , Lymphocytes , Sexual Infantilism , UterusABSTRACT
Castleman disease is a rare disease entity of unknown etiology, with the characteristics of large, wellmarginated benign lymphoid masses occuring predominently in the mediastinum. the value of contrast enhancement insolid soft tissue masses of mediastinum has little been written because most of the solid mediastinal tumors showno significant degree of enhancement. But Castleman disease, because of its hypervascularity, shows significantdegree of enhancement in most cases. Authors report 3 cases of Castlemen disease and suggests good diagnosticprobability of Castlman disease in cases that show benign looking homogeneously enhancing mediastinal mass by CTscan.
Subject(s)
Castleman Disease , Lymph Nodes , Mediastinum , Rare DiseasesABSTRACT
It is generally agreed that CT is a good staging method of renal cell carcinoma. However, CT has its ownpitfalls. Herein we reviewed 31 patients with renal cell carcinoma whose CT and pathologic stages were available.CT accurately staged 12 of 14 patients with Robson's stage I (86%), 6 of 8 with stage II (75%), 4 of 4 with stageIIIa (100%), 2 of 3 with stage IIIb (67%), and 1 of 2 with stage IV (50%). Overall staging accuracy of CT was 81%(25 of 31). CT failed to differentiate stage I and stage II in 4 cases. CT also failed to diagnose the microscopiclymph node metastasis in 1 case, and invasion of Gerota's fascia in another case. However CT was satisfactory indifferentiating surgically curable stage I to III from surgically incurable stage IV, and high reliable in thediagnosis of inferior vena caval thrombosis. Therefore it is suggested that CT is highly useful in determining thetreatment plan of renal cell carcinoma.
Subject(s)
Humans , Carcinoma, Renal Cell , Fascia , Methods , Neoplasm Metastasis , ThrombosisABSTRACT
Accurate preoperative CT staging of renal tumor affects the therapeutic approach and aids the urologist in planning the appropriate procedure. CT staging were compared in 33 patients with pathologically confirmed stage of renal tumor. The overall accuracy of CT staging in renal cell carcinoma is 87.0%. The overall accuracy of CT staging in renal pelvis tumor is 80.0%. The major role of CT was in the evaluation of renal capsule, perirenal fat, Gerota's fascia, renal vein, inferior vena cava and lymph node for invasion. We conclude that at the present time CT is the optimal technique to stage renal tumor.