ABSTRACT
The authors report the clinical features, radiologic findings and the operative management of three patients with tentorial free edge meningioma. The frequent symptoms and signs were headache, facial pain, tinnitus, dizziness, increased intracranial pressure and cranial nerves deficits. Tentorial free edge meningiomas are not only very rare but also very difficulty in total removal without complications. In this presentation, we are discussed the nature of this tumor and operative technique with review of literature.
Subject(s)
Humans , Cranial Nerves , Dizziness , Facial Pain , Headache , Intracranial Pressure , Meningioma , TinnitusABSTRACT
The eight patients of neurocysticercosis have been diagnosed from 1985 to 1987 in the department of neurosurgery at The Baptist Hospital. Six patients had parenchymal cysts, one had a racemose cyst and the other one had a mixed cyst. The blood serum and CSF ELISA on six patients had a positive reaction for cysticercosis but the follow-up ELISA titers were variable three months later on these four. The racemose and mixed cysts were removed surgically due to mass effect and followed by praziquantel therapy. The parenchymal cysts were treated with praziquantel only. Praziquantel was given daily at 50mg/kg of body weight for two weeks or 30mg/kg of body weight for three weeks. The common side effects of praziquantel were headache, dizziness, nausea, seizure and focal neurological deficits. These side effects could be prevented or minimized by corticosteroid. The result of praziquantel therapy was excellent in all the patients except the mixed cyst.
Subject(s)
Humans , Body Weight , Cysticercosis , Dizziness , Enzyme-Linked Immunosorbent Assay , Follow-Up Studies , Headache , Nausea , Neurocysticercosis , Neurosurgery , Praziquantel , Protestantism , Seizures , SerumABSTRACT
The eight patients of neurocysticercosis have been diagnosed from 1985 to 1987 in the department of neurosurgery at The Baptist Hospital. Six patients had parenchymal cysts, one had a racemose cyst and the other one had a mixed cyst. The blood serum and CSF ELISA on six patients had a positive reaction for cysticercosis but the follow-up ELISA titers were variable three months later on these four. The racemose and mixed cysts were removed surgically due to mass effect and followed by praziquantel therapy. The parenchymal cysts were treated with praziquantel only. Praziquantel was given daily at 50mg/kg of body weight for two weeks or 30mg/kg of body weight for three weeks. The common side effects of praziquantel were headache, dizziness, nausea, seizure and focal neurological deficits. These side effects could be prevented or minimized by corticosteroid. The result of praziquantel therapy was excellent in all the patients except the mixed cyst.
Subject(s)
Humans , Body Weight , Cysticercosis , Dizziness , Enzyme-Linked Immunosorbent Assay , Follow-Up Studies , Headache , Nausea , Neurocysticercosis , Neurosurgery , Praziquantel , Protestantism , Seizures , SerumABSTRACT
The reports of epidural vascular tumors are rare however dumbbell-shaped epidural cavernous hemangioma is exceedingly rare. The reported incidence of epidural hemangiom is 4%of all spinal epidural tumors and 12% of all intraspinal hemangioma. In the majority of cases, hemangiomas of spinal epidural space represent the secondary extension of a vertebral hemangioma but the occurance of pure epidural cavernous hemangioma is relatively rare. In this report, authors present two cases of epidural cavernous hemangioma including one dembbell-shaped in the thoracic spine with review of other reports.
Subject(s)
Epidural Neoplasms , Epidural Space , Hemangioma , Hemangioma, Cavernous , Incidence , SpineABSTRACT
A possible drug interaction between phenytoin and dexamethasone was evaluated by comparing serum phenytoin concentrations in 34 patients receiving both drugs with those if a control group 19 patients receiving phenytoin only. Serum phenytoin concentrations obtained 24 hours after a loading dose of 15mg per kilogram body weight administrated intravenously were examined. The serum concentrations of phenytoin were checked by homogenous enzyme immunoassay(EMIT) method. The total amounts of dexamethasone administered during the 24 hours period ranged from 10 to 40mg. The average serum phenytoin concentration was 12.08+/-2.78 microgram/ml in patients receiving both drugs, as compared to 8.58+/-2.72 microgram/ml in patients receiving phenytoin only(p<0.005). Our results suggest that serum phenytoin concentrations in patients receiving both drugs were higher than in patients receiving phenytoin only.
Subject(s)
Humans , Body Weight , Dexamethasone , Drug Interactions , PhenytoinABSTRACT
The study was undertaken to determine the cardiovascular response to spinal cord trauma and to determine the autonomic mechanisms involved. The arterial pressure was recorded in anesthetized cats during spinal cord trauma of 50gm-cm at T4-T6 levels. The spinal cord trauma resulted in a sudden increase of systemic blood pressure from a control level of 92mmHg to 140mmHg, an increase of 52%, at 45 seconds. This initial hypertensive plase lasted approximately 3 to 4 minutes, and then was followed by a hypotensive phase. 2) This pressor response was mediated by an beta-adrenergic blocking agent. 3) During the hypertensive phase, the pulse pressure was increased while the heart rate was decreased, The pulse pressure and the heart rate changed symmetrically, showing the maximal elevation and minimal decrease at 20 seconds, respectively. These results suggest that the alternations in blood pressure that follow the spinal cord trauma are most likely related to alternations of peripheral arteriolar resistance and venous return of blood to the heart.