ABSTRACT
Infantile hepatic hemangioma is benign vascular tumor and the most common liver tumor in infants. Small hepatic hemangioma is usually asymptomatic and seldom require therapy. Giant hepatic hemangioma, defined as more than 4 cm in diameter, is rare, but can lead to life-threatening complications such as consumptive coagulopathy, anemia, hemorrhage after tumor rupture and congestive heart failure due to arteriovenous shunting. Neonatal mortality rate is about 70-90%. The differential diagnosis of a fetal liver mass includes hemangioma, hepatoblastoma, and mesenchymal harmatoma. Although hepatic hemangioma represents the most common tumor of the liver in infant, the prenatal diagnosis of this condition has been rarely reported in the literature. we experienced a case of fetal hepatic hemangioma by prenatal sonography and report our case with a brief review of literature.
Subject(s)
Humans , Infant , Anemia , Diagnosis , Diagnosis, Differential , Heart Failure , Hemangioma , Hemorrhage , Hepatoblastoma , Infant Mortality , Liver , Prenatal Diagnosis , Rupture , UltrasonographyABSTRACT
OBJECTIVE: The HCV seroprevalence rate and the vertical transmission rate in Korean pregnancy women have not been determined until now. The purpose of this study is to estimate the prevalence of anti- HCV in pregnant women and vertical transmission rate to assess the role of antenatal screening of HCV and the necessity of following babies from anti-HCV positive mothers. METHODS: We reviewed the medical records of 21,639 patients who delivered at Ilsin Christian hospital from January 2000 to October 2003. The HbsAg, HbsAb, anti-HCV, HIV test were performed in their 1st trimester of pregnancy and the HCV RNA test was performed by RT-PCR in samples positive for anti-HCV. 38 babies born to anti-HCV positive mothers were tested for anti-HCV and those who were positive anti-HCV were also tested for HCV RNA by PCR. RESULTS: The positive rate of anti-HCV in pregnant women was 0.42% (90/21,639) and that of HCV RNA was 57% (51/90). The positive rate of anti-HCV was 26.3% (10/38) and the result of HCV RNA test was all negative in babies whose mothes were positive for anti-HCV. CONCLUSION: The prevalence of anti-HCV in pregnant women who delivered at our hospital seems to be higher than that in the Korean young adult man and it is similar with the whole world prevalence rate. The prevalence of anti-HCV of babies born to HCV PCR positive mothers was higher than that born to HCV PCR negative mothers. None of anti-HCV positive babies was HCV RNA positive. With this, we conclude that the vertical transmission as the transmission route of HCV infection is negligible but routine screening for HCV is acceptable to pregnant women.
Subject(s)
Female , Humans , Pregnancy , Young Adult , Hepatitis B Surface Antigens , HIV , Mass Screening , Medical Records , Mothers , Moths , Polymerase Chain Reaction , Pregnant Women , Prenatal Diagnosis , Prevalence , RNA , Seroepidemiologic StudiesABSTRACT
Complete trisomy 9 is a rare chromosomal aneuploidy in live born infants. The majority of cases of trisomy 9 end in spontaneous abortion in the first trimester. Clinical finding of co-mplete trisomy 9 demonstrate multiple organ abnormalities in the craniofacial, cardiovascular, skeletal, genitouronary systems. We report a fetus with Dandy Walker syndrome which was diagnosed prenatally and was subsequently found to have a complete trisomy 9.