ABSTRACT
Lipomatous neurofibroma is a recently described, very rare variant of neurofibroma. It shows a well-circumscribed nodule consisting of fascicles or whorls of spindle cells with an extensive lipomatous component. These fat cells are considered to be an integral part of this tumor, not a metaplastic or degenerative process. It may be due to the differentiation of local stem cells of neural crest. Herein we report a case of lipomatous neurofibroma, the rare pathological variant of neurofibroma with extensive mature fat cells.
Subject(s)
Adipocytes , Neural Crest , Neurofibroma , Stem CellsABSTRACT
Basal cell carcinoma (BCC) is noted for its many histologic variants because of its pluripotential origin from epithelial germ cells. Clear cell BCC has been recognized as a distinct variant and has a clear cell component made up of cells which are either vacuolated or display a finely granular eosinophilic cytoplasm. We report a case of clear cell BCC in a 62-year-old man who had a well-demarcated, skin-colored nodule on the left nasal ala. It was treated by surgical excision with a Burow's graft and no recurrence has been observed.
Subject(s)
Humans , Middle Aged , Carcinoma, Basal Cell , Cellular Structures , Cytoplasm , Eosinophils , Germ Cells , Recurrence , TransplantsABSTRACT
BACKGROUND: Scleredema is a rare connective tissue disorder, characterized by hard and thick skin. It is well known that collagen synthesis is increased in scleredema skin, but there has been no study on the change of elastic fibers. OBJECTIVE: The purpose of this study was to compare the changes of collagen and elastic fibers in scleredema and normal skin. METHODS: We retrospectively evaluated the biopsy specimens of 10 patients diagnosed with scleredema. The control group was selected by matching each scleredema case with same site and similar ages from the biopsy specimens which showed normal dermis. A computerized image analysis system was used to measure the fraction of collagen and elastic fibers and calculate the ratio of elastic fibers to collagen fibers in each group. RESULTS: The skin of scleredema was found to have a significant increase in the percentage of collagen fibers in the dermis compared to the control group. On the other hand, the percentage of elastic fibers was significantly decreased in the scleredema group (p<0.05). CONCLUSION: In contrast to scleroderma which shows an increase in dermal elastic tissue and collagen fibers, we concluded that there is a decrease of elastic fibers in scleredema and that the pathogenesis and molecular involvement are different in the two diseases. we also found that the computerized image analysis system was a useful tool in the measurement of connective tissue components.
Subject(s)
Humans , Biopsy , Collagen , Connective Tissue , Dermis , Elastic Tissue , Hand , Retrospective Studies , Scleredema Adultorum , SkinABSTRACT
Fibroma of tendon sheath is a benign, soft tissue tumor that presents as a painless mass in the distal portion of an extremity. It is a slow-growing, dense, fibrous nodule which firmly attaches to the tendon sheath, and usually occurs in adults between the age of 20 and 50 years old. Histopathologically, it shows a well-demarcated nodule consisting of haphazardly-arranged, fibroblast-like spindle cells, which are embedded in a dense collagenous matrix. It is thought to be either a reactive process or a neoplasm, and the recurrence rate after excision is reported to be 24%. Herein, we present a typical case of fibroma of tendon sheath in a 39-year-old female, who presented with a firm nodule on her left 2nd finger. This was confirmed by histopathologic findings. The information described above should carefully be taken into consideration during differential diagnosis of soft tissue tumors of the hand.
Subject(s)
Adult , Female , Humans , Middle Aged , Collagen , Diagnosis, Differential , Extremities , Fibroma , Fingers , Hand , Recurrence , TendonsABSTRACT
Zosteriform lichen planus is a rare variant of lichen planus, which shows lichenoid papules in a dermatomal arrangement. Unlike the linear lichen planus developing a linear pattern, zosteriform lichen planus forms a broader band that follows the dermatomes. A few cases of zosteriform lichen planus occurring on the site of healed herpes zoster have been reported, and were assumed to represent Wolf's isotopic response. However, even fewer cases have been reported that developed without any previous history of herpes zoster. We present a 32-year-old male patient who showed a hyperpigmented papuloplaques in a zosteriform arrangement along the right upper back, shoulder and arm without a history of herpes zoster.
Subject(s)
Adult , Humans , Male , Arm , Herpes Zoster , Lichen Planus , Lichens , ShoulderABSTRACT
Primary cutaneous diffuse large B-cell lymphoma is characterized by a diffuse infiltration of atypical large centroblasts and immunoblasts through the dermis without extracutaneous involvement. We report a case of primary cutaneous diffuse large B-cell lymphoma in a 71-year-old female, who presented with a solitary erythematous nodule on the inner thigh. Physical examination and staging work-up revealed no other extracutaneous or systemic involvement. After radiotherapy, the skin lesion had almost cleared, and no evidence of extracutaneous involvement was observed for 4 months.
Subject(s)
Aged , Female , Humans , B-Lymphocytes , Dermis , Lymphoma, B-Cell , Physical Examination , Radiotherapy , Skin , ThighABSTRACT
Chilblain lupus erythematosus is a special, relatively rare subtype of chronic cutaneous lupus erythematosus. Usually, discoid lesions precede or occur concurrently with perniotic lesions, and about 20% of the patients later develop systemic lupus erythematosus. Herein, we present a 26-year-old female patient who developed erythematous to purplish scaly and crusted papules on the palms, fingers and toes. She also had erythematous hyperkeratotic plaques on the ears and scalp with scarring alopecia that was consistent with discoid lupus erythematosus. Histopathologic finding revealed perivascular and periappendigeal lymphocytic infiltration and fibrin deposition in dermal blood vessels. Therefore, this represents a case of chilblain lupus erythematosus which is a rare subtype and shows typical clinical and histopathologic findings.
Subject(s)
Adult , Female , Humans , Alopecia , Blood Vessels , Chilblains , Cicatrix , Ear , Fibrin , Fingers , Lupus Erythematosus, Cutaneous , Lupus Erythematosus, Discoid , Lupus Erythematosus, Systemic , Scalp , ToesABSTRACT
Malignant nodular hidradenoma was first reported by Liu in 1949, and it is an uncommon appendage tumor that presents on head, trunk, or extremities. It has been known as nodular hidradenocarcinoma, malignant clear cell hidradenoma, clear cell hidradenocarcinoma, and accepted as a tumor of the eccrine sweat glands. Histopathologically, tumor is composed of lobulated masses and contains tubular structures with cystic space formation. The cells forming the nest have two populations of clear cells and basophilic polyhedral cells. We report a case of malignant nodular hidradenoma composed of a small proportion of clear cells.