A Case of Duodenal Diverticulitis Mimicking Cholangitis / 대한소화기내시경학회지

The duodenum ranks second to the colon as the most common site of diverticulosis in the gastrointestinal tract with a prevalence of more than 20%. It is usually asymptomatic, and rarely requires treatments for complications, including diverticulitis, hemorrhage, and luminal obstructions. Unlike diverticulosis, duodenal diverticulitis is extremely rare. Given that the radiological appearance and clinical presentation of duodenal diverticulitis often mimic those of pancreaticobiliary neoplasms or inflammations, it is a challenge for clinicians to diagnose it correctly, which often leads to misdiagnosis and inappropriate management. Here we report a case of a 69 year-old female patient with duodenal diverticulitis, whose clinical symptoms and radiological images were similar to those of acute cholangitis. We also briefly review the literature.

Treatment of Idiopathic Genu Varum Using Tibiofibular Osteotomy and External Fixation / 대한정형외과학회잡지

PURPOSE: This paper examined the results of a tibiofibular osteotomy and external fixation in idiopathic genu varum. MATERIALS AND METHODS: Ten patients (20 cases) with idiopathic genu varum were treated with a tibiofibular osteotomy and external fixation. The average follow-up period was 13 months (range, 6-27). The average age of the patients was 23.1 (range, 16-39). A tibial osteotomy was performed an average 9.1 cm (range, 5-13.5) distal to the tibial spine, which was 2 cm distal to the center of the rotation axis (CORA). RESULTS: The preoperative anatomical tibio-femoral angle of varus, 7.0o (range, 4-10), was corrected to valgus 0.8o (range, varus 5-valgus 6). After surgery, the femur intercondylar distance of 5.3 cm (range, 4-7) was improved to 0.4 cm (range, 0.5-4), and the preoperative average maximal intercalf distance of 11.2 cm (range, 8.5-13) was improved to 6.5 cm (range, 4-9). A preoperative mechanical axis deviation of 2.0 cm (range, 0-3.5) improved to 0.3 cm (range, 0-2.3). The complications encountered were 4 cases of a pin site infection, 1 case of a superficial peroneal sensory nerve injury, 1 case of a deep peroneal nerve partial injury and 2 cases of a popliteal artery partial occlusion. CONCLUSION: The tibiofibular osteotomy and external fixation is considered to be an effective method for treating an idiopathic genu varum with early ROM and weight bearing. However, surgeons need to pay careful attention in order to prevent a neurovascular complications.

The Effect of Halothane and Isoflurane on KCNK2 Transfected HEK-293 Cells / 대한마취과학회지

BACKGROUND: According to the report that KCNK activity in transfected COS-7 and HEK-293 cells was modulated by volatile anesthetics and activation of KCNK channels by neuroprotectants, the importance of KCNK2 were emphasized. In this study, we studied the effect of halothane and isoflurane on KCNK2 in the KCNK2 transfected HEK-293 cells. METHODS: Multiple patch clamp experiments with halothane and isoflurane were conducted to characterize KCNK2 in the KCNK2 transfected HEK-293 cells. KCNK2 cDNA were transiently transfected with FuGENE6 transfection reagents and whole cell recordings were made using predesigned pulse protocol. RESULTS: KCNK2 transfected HEK cells exhibited rapid rising, a time-independent, non-inactivating, outward-rectifying currents and had no threshold for activation by voltage. Multiple patch clamp experiments showed the presence of outward-rectifying K+ selective channels with a conductance of 1.31 +/- 0.59 nS (n = 16) at positive potentials. Recordings of halothane 448microM (-2 MAC) increased outward currents from control by 218% in standard saline perfusate (n = 4, P<0.05, paired t-test) and that of isoflurane 822microM (-3 MAC) increased outward currents by 172% in standard saline perfusate (n = 12, P<0.05, paired t-test). Channel activity enhanced during the duration of the exposure to volatile anesthetics returned to the baseline quickly upon wash. CONCLUSIONS: Considering the activation of KCNK2 by neuroprotectants such as riluzole and PUFA, we might think of the possibility of halothane and isoflurane as neuroprotectants because these anesthetics activated background K+ channels in KCNK2 transfected HEK-293 cells.

Radiological Comparison between 60 degrees Distal Chevron Osteotomy and 40 degrees Distal Chevron Osteotomy in Hallux Valgus / 대한족부족관절학회지

PURPOSE: We made a radiological comparison between 60 degrees distal Chevron osteotomy with short armed two parts and 40 degrees distal Chevron osteotomy with long armed one part performing operation in cases of hallux valgus angle of less than 40 degrees, intermetatarsal angle of less than 15 degrees. MATERIALS AND METHODS: 12 cases with 60 degrees distal Chevron osteotomy and 12 cases with 40 degrees distal Chevron osteotomy were selected from October 2000 to March 2005. We have analysed the hallux valgus angle, 1-2 intermetatarsal angle, metatarsal length, distal metartarsal articular angle and angulation at osteotomy site on lateral view in each radiological films taken at preoperative, postoperative and 3 months after operation presuming bone union. All cases were women, both sides were 9 cases and average age was 52.3 years old. RESULTS: Data taken at preoperative, postoperative and 3 months follow up films in 60 degrees distal Chevron osteotomy were as follows; the hallux valgus angles were 32.1 degrees, 10.9 degrees, 13.8 degrees, the 1-2 intermetatarsal angles were 13.6 degrees, 8.5 degrees, 8.4 degrees, the metatarsal length were 60.6 mm, 58.8 mm, 58 mm, the distal metartarsal articular angles were 13 degrees, 6 degrees, 6.6 degrees and 3 cases were over 3 degrees angulation at lateral view. In 40 degrees distal Chevron osteotomy, the hallux valgus angles were 34.5 degrees, 11.6 degrees, 15.3 degrees, the 1-2 intermetatarsal angles were 12.7 degrees, 8.2 degrees, 7.8 degrees, the metatarsal length were 59.2 mm, 56.9 mm, 55.9 mm, the distal metartarsal articular angles were 12 degrees, 7.3 degrees, 7.3 degrees and there were no case with angulation over 3 degrees at lateral view. CONCLUSION: In comparison between 60 degrees distal Chevron osteotomy and 40 degrees distal Chevron osteotomy measuring at postoperative and follow up, most of all data were similar, but 3 cases over 3 degrees angulation at lateral view happened in 60 degrees Chevron osteotomy. This result showed that 40 degrees distal Chevron osteotomy fixing with screws through long armed one part may have benefit than 60 degrees distal Chevron osteotomy fixing with K-wires through short armed two parts in making rigid fixation, even though there is a personal difference of technigue.

Radiological Comparison between 60 degrees Distal Chevron Osteotomy and 40 degrees Distal Chevron Osteotomy in Hallux Valgus / 대한족부족관절학회지

PURPOSE: We made a radiological comparison between 60 degrees distal Chevron osteotomy with short armed two parts and 40 degrees distal Chevron osteotomy with long armed one part performing operation in cases of hallux valgus angle of less than 40 degrees, intermetatarsal angle of less than 15 degrees. MATERIALS AND METHODS: 12 cases with 60 degrees distal Chevron osteotomy and 12 cases with 40 degrees distal Chevron osteotomy were selected from October 2000 to March 2005. We have analysed the hallux valgus angle, 1-2 intermetatarsal angle, metatarsal length, distal metartarsal articular angle and angulation at osteotomy site on lateral view in each radiological films taken at preoperative, postoperative and 3 months after operation presuming bone union. All cases were women, both sides were 9 cases and average age was 52.3 years old. RESULTS: Data taken at preoperative, postoperative and 3 months follow up films in 60 degrees distal Chevron osteotomy were as follows; the hallux valgus angles were 32.1 degrees, 10.9 degrees, 13.8 degrees, the 1-2 intermetatarsal angles were 13.6 degrees, 8.5 degrees, 8.4 degrees, the metatarsal length were 60.6 mm, 58.8 mm, 58 mm, the distal metartarsal articular angles were 13 degrees, 6 degrees, 6.6 degrees and 3 cases were over 3 degrees angulation at lateral view. In 40 degrees distal Chevron osteotomy, the hallux valgus angles were 34.5 degrees, 11.6 degrees, 15.3 degrees, the 1-2 intermetatarsal angles were 12.7 degrees, 8.2 degrees, 7.8 degrees, the metatarsal length were 59.2 mm, 56.9 mm, 55.9 mm, the distal metartarsal articular angles were 12 degrees, 7.3 degrees, 7.3 degrees and there were no case with angulation over 3 degrees at lateral view. CONCLUSION: In comparison between 60 degrees distal Chevron osteotomy and 40 degrees distal Chevron osteotomy measuring at postoperative and follow up, most of all data were similar, but 3 cases over 3 degrees angulation at lateral view happened in 60 degrees Chevron osteotomy. This result showed that 40 degrees distal Chevron osteotomy fixing with screws through long armed one part may have benefit than 60 degrees distal Chevron osteotomy fixing with K-wires through short armed two parts in making rigid fixation, even though there is a personal difference of technigue.

Fine Classification and Treatment Outcome of Lateral Condyle Fracture of the Humerus in Children / 대한정형외과학회잡지

PURPOSE: This paper reports the outcome and complications of a lateral condyle fracture of the humerus in children treated by the fine classification of Jakob stage. MATERIALS AND METHODS: Forty-five cases of a lateral condyle fracture of the humerus in children were treated according to the fine classification of the Jakob stage. There were 4 cases of Jakob stage Ia fractures treated with the application of a simple cast; 16 cases of Jakob stage Ib & IIa fractures treated with a closed reduction and k-wire pinning; and 25 cases of Jakob stages IIb & III fractures treated with an open reduction and K-wire pinning. The average follow-up period was 25 months. RESULTS: Postoperative complications were seen in 18 cases. As minor complications, there were 2 cases of delayed union, 5 cases of hypertrophy of the lateral condyle and 10 cases of osteophyte formation. As major complications, 1 case of avascular necrosis and limitation of motion developed. There were no serious complications such as nonunion, malunion, ectopic ossification, early arrest of the growth plate, and nerve injury. The clinical outcomes were excellent in all but one case of a joint motion limitation. CONCLUSION: The fine classification of the Jakob stage is effective in determining the treatment method for lateral condyle fractures of the humerus in children.

Protective Effect of Propofol on Endothelial Damage Induced by Reactive Oxygen Species in Rabbit / 대한마취과학회지

BACKGROUND: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in the isolated rabbit thoracic aorta. The aim of this study was to explore the influence of the propofol and midazolam against ROS in the isolated rabbit thoracic aortic endothelium. METHODS: Eighteen white male rabbits (weighing 2.0-2.5 kg) were used. The thoracic aorta was dissected free and cut into rings (3-4 mm) and then suspended in a organ bath filled with 10 ml Krebs solution bubbled with 5% CO2 95% O2 at 37 degrees C. Aortic rings were then equilibrated for 90 min, and a resting tension of 1.5 g was applied. The Krebs solution was changed every 15 min. Isometric tension was recorded with transducer coupled to a data acqusition system (Biopac Inc. USA) on a PC. After precontraction with norepinephrine (NE, 10(-6)M), changes in tension were measured following the cumulative administration of acetylcholine (ACh 3x10(-7), 10(-6) and 3x10(-6)M) and nitroglycerin (NTG, 10(-5)M). Data are expressed as percentage of the 10 5 M NTG-induced relaxation (ACh/NTG). The ACh/NTG, before and after electrolysis were defined as the control and the experimental groups. The aortic rings were pretreated with propofol (3x10(-5), 10(-4), 3x10(-4) and 5.7x10(-4) M, n = 8, 10, 15, 13), midazolam (10(-4)M, n = 7), catalase (1,000 U/ml, n = 12), mannitol (3x10(-4)M, n = 5) or not pretreated group (Free, n = 6). After 30 minutes, the aortic rings were exposed to ROS generated by electrolysis (DC 9 V, 20 mA, aortic rings 1 cm away from electrode) in Krebs solution for 2 minutes, which was then changed for physiologic buffered salt solution. The aortic rings were precontracted with NE and vasorelaxation was induced with ACh and NTG at the above mentioned concentrations. RESULTS: Propofol produced vasorelaxation of NE-precontracted thoracic aorta in a dose-dependent fashion in all groups of propofol (3x10(-5), 10(-4), 3x10(-4) and 5.7x10(-4)M) even after ROS attack (P < 0.05 vs control value). Catalase produced vasorelaxation after ROS attack (P < 0.05 vs control value).On the other hand, ACh-induced significant endothelium-dependent vasorelaxation were not observed in the midazolam or mannitol pretreated group or the non-pretreated group (P <0.05 vs control group). CONCLUSIONS: These findings suggest that propofol and catalase preserve ACh induced endothelium-dependent vasorelaxation and that propofol has a concentration dependent ROS scavenging effect like catalase.

Evaluation of Prognosis in Esophageal Atresia

The aims of this study were to evaluate the prognostic predictabilities of the risk classifications (Waterston, Montreal, and Spitz), preoperative treatment of pneumonia and the length of esophageal gap in esophageal atresia. Twenty-five cases of esophageal atresia were reviewed retrospectively. The data was analyzed with Likelihood ratio test for trend and Fisher's exact test. Survival rates were 100.0% in group A and B, and 60.0% in group C according to Waterston classification (p=0.027). By Montreal classification, 95.7% in group I and 50.0% in group II (p=0.086). By Spitz classification, 95.5% in group I and 66.7% in group II (p=0.159). The survival rate was 85.7% in the patients with pneumonia preoperatively treated and 94.4% in the patients without pneumonia. The difference was not significant (p=0.490). Survival rate in the patients with long gap (> or = 3cm) was 50.0% and 100.0% in patients with short gap (< 3cm) with significant difference (p=0.020). The Waterston classification could be modified into two groups because the prognosis of both group A and B were the same. Preoperative pneumonia does not seem to be a risk factor. The length of the esophageal gap showed prognostic value.

The Result of Delayed Operation in Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) in the past was considered a surgical emergency requiring immediate operation. Several groups now advocate preoperative stabilization and delayed surgery. The treatment strategy for CDH in this institution is delayed surgery after preoperative stabilization. The aim of this study was to evaluate the results of delayed surgery. A retrospective review of 16 neonates with CDH was performed. Surfactant, conventional mechanical ventilation, high frequency oscillation, and nitric oxide were utilized for preoperative stabilization as necessary. The difference in outcome between two groups differentiated by the duration of the preoperative stabilization periods with mechanical ventilation (8 hours) was determined. Chi-square test was used to analyze the data. There were 7 right-sided hernias and 9 left. The average duration of stabilization was 32.4 hours. Hepatic herniation through the defect was found in 6 cases and all died. The most common postoperative complication was pneumothorax. The mortality rate of the right side hernia was higher than the left (85.7% vs. 33.3%, p=0.036). Mortality rate of the group (N=8) whose preoperative stabilization period was 8 hours or less was better than that (N=6) whose preoperative stabilization period was more than 8 hours (25.0% vs. 83.3%, p=0.031). The overall mortality rate was 56.3%. The better prognosis was noticed in left side hernia, no liver herniation, or shorter preoperative stabilization period.

OK-432 Intralesional Injection Therapy for Lymphangioma in Children

Lymphangioma is a congenital malformation of the lymphatic system, commonly seen in the neck. Operation was the treatment of choice but it is difficult to resect the lymphangiomas completely. The aim of this study is to evaluate the result of intralesional injection of OK-432 as a treatment strategy of lymphangioma in children. Medical records of 51 cases of lymphangioma from March 1996 to February 2001 were reviewed retrospectively. Intralesional injection of 0.1 mg OK-432 in 10ml normal saline was performed after the aspiration of as much fluid as possible. The location of the lesion was the face and neck in 26 patients, the chest wall in 14, the extremities in 9, and the abdominal wall in 2. The cystic type was present in 45 patients and the cavernous type in 6. Four postoperative recurrent cases were included. Fluid aspiration from the lesion was impossible in 5 patients. Development of fever after injection was observed in 27 patients and local inflammatory reaction was in 5 patients. There was no scar formation at injection sites. Complete shrinkage was observed in 20 patients, remarkable shrinkage in 23, slight shrinkage in 3, and no response in 5. Cystic type or aspiration-possible cases showed better outcome than cavernous type or aspiration-impossible cases. All of four recurrent cases after surgical excision showed at least remarkable shrinkage. These results indicate that intralesional injection of OK-432 is a safe and satisfactory treatment modality of lymphangiomas in children and might be considered as a treatment of choice, even in recurrent cases.

A Study on the Effect of Degree of Freedom of Ankle Motion on Gait of Transfemoral Amputees with SNS Control Prosthesis / 대한정형외과연구학회지

Using three different types of the ankle joint, i.e., the fixed, single-axis, and multi axis type, the gait characteristics of transfemoral amputees were investigated to understand the biomechanics of ankle joint motion during gait of transfemoral amputees with a SNS (swing and stance phase) control prosthesis controlling the flexion-extension of knee in the stance phase unlike conventional swing control prostheses. The socket pressure was measured to explain the resulting gait characteristic of the transfemoral amputees for different ankle joint components. Based on the results from the gait characteristics, socket pressure, knee flexion-extension behavior, and ground reaction vector, the fixed type ankle joint could be considered as the most appropriate ankle joint for the transfemoral amputees using the SNS control prosthesis.

A Study on the Effect of Degree of Freedom of Ankle Motion on Gait of Transfemoral Amputees with SNS Control Prosthesis / 대한정형외과연구학회지

Using three different types of the ankle joint, i.e., the fixed, single-axis, and multi axis type, the gait characteristics of transfemoral amputees were investigated to understand the biomechanics of ankle joint motion during gait of transfemoral amputees with a SNS (swing and stance phase) control prosthesis controlling the flexion-extension of knee in the stance phase unlike conventional swing control prostheses. The socket pressure was measured to explain the resulting gait characteristic of the transfemoral amputees for different ankle joint components. Based on the results from the gait characteristics, socket pressure, knee flexion-extension behavior, and ground reaction vector, the fixed type ankle joint could be considered as the most appropriate ankle joint for the transfemoral amputees using the SNS control prosthesis.

A Case of Gastric Volvulus

Gastric volvulus is a rare surgical disorder in the pediatric population. We experienced a case of gastric volvulus. A 2-year-old boy was admitted to hospital with abdominal distension. An upper gastrointestinal series showed reversal of the greater and lesser curvatures. Surgical exploration revealed an organoaxial volvulus of the stomach, and anterior gastropexy was performed.

Muscle Relaxation and Cardiovascular Response in Rabbits by Pancuronium and Verapamil / 대한마취과학회지

Pancuronium is one of the most available nondepolarizing muscle relaxant. It is primarily eliminat-ed unchanged by the kidney, although a small fraction is metabolized by the liver. On the other hand, calcium channel blocking agents are a chemically heterogeneous group of drugs that inhibit the ionic current carried through the calcium slow channel in cardiac and vascular smooth muscle. This action is the basis of their usefulness in the treatment of cardiovascular disorders. Although the role of calcium in skeletal muscle differs from that in cardiac and vascular smooth muscle, various recent studies have shown that verapamil is able to inhibit neuromuscular function in skeletal muscle preparations. However, it is not well known, yet. Increasing number of patients who are taking calcium channel blockers were reported recently. The present study was undertaken to determine if verapamil could potentiate the effects on pancuronium and how does it affect the cardiovacular response. The results were as follows; 1. Verapamil (1.41 mg) significantly enhanced the recovery index of pancuronium as 226.7 sec compared with control recovery index as 162.5 sec (p<0.025). But tetanic stimulation (50Hz, 5 sec) was sustained in the both group. 2. Hypotensive effect was appeared when 1.41 mg of verapamil was given and it was taken 7.7 min. 3. Signs of cardiovascular response was decreasing the blood pressure especially diastolic first then heart rate was decreased.

Cardiac Toxicity on Mixtures of Bupivacaine and Lidocaine in Rabbits / 대한마취과학회지

Mixtures of local anesthetics can combine the hest features of both components. The authors assayed the cardiac toxicity of local anesthetic mixtures given intravenously to rabbits. Arrhythmia was appeared at 200-150 beats/min. of pulse rate and tendency of arrhythmia in bupivacaine was increased about 16-17 times more than that of lidocaine. Mean arterial blood pressure before the study was about 92 mmHg, but it was down to about 53-74 mmHg after arrhythmia appeared. Lethal doae of bupivacaine was one-seventh that of lidocaine during infusion. None of the mixtures were more lethal than their parent components; bupivacaine containing mixtures were significantly less lethal than the bupivacaine alone. The toxicity of local anesthetic mixtures was essentially additive not synergistic.

Muscle Relaxation and Cardiovascular Response in Rabbits by Pancuronium and Verapamil / 대한마취과학회지

Pancuronium is one of the most available nondepolarizing muscle relaxant. It is primarily eliminat-ed unchanged by the kidney, although a small fraction is metabolized by the liver. On the other hand, calcium channel blocking agents are a chemically heterogeneous group of drugs that inhibit the ionic current carried through the calcium slow channel in cardiac and vascular smooth muscle. This action is the basis of their usefulness in the treatment of cardiovascular disorders. Although the role of calcium in skeletal muscle differs from that in cardiac and vascular smooth muscle, various recent studies have shown that verapamil is able to inhibit neuromuscular function in skeletal muscle preparations. However, it is not well known, yet. Increasing number of patients who are taking calcium channel blockers were reported recently. The present study was undertaken to determine if verapamil could potentiate the effects on pancuronium and how does it affect the cardiovacular response. The results were as follows; 1. Verapamil (1.41 mg) significantly enhanced the recovery index of pancuronium as 226.7 sec compared with control recovery index as 162.5 sec (p<0.025). But tetanic stimulation (50Hz, 5 sec) was sustained in the both group. 2. Hypotensive effect was appeared when 1.41 mg of verapamil was given and it was taken 7.7 min. 3. Signs of cardiovascular response was decreasing the blood pressure especially diastolic first then heart rate was decreased.

Cardiac Toxicity on Mixtures of Bupivacaine and Lidocaine in Rabbits / 대한마취과학회지

Mixtures of local anesthetics can combine the hest features of both components. The authors assayed the cardiac toxicity of local anesthetic mixtures given intravenously to rabbits. Arrhythmia was appeared at 200-150 beats/min. of pulse rate and tendency of arrhythmia in bupivacaine was increased about 16-17 times more than that of lidocaine. Mean arterial blood pressure before the study was about 92 mmHg, but it was down to about 53-74 mmHg after arrhythmia appeared. Lethal doae of bupivacaine was one-seventh that of lidocaine during infusion. None of the mixtures were more lethal than their parent components; bupivacaine containing mixtures were significantly less lethal than the bupivacaine alone. The toxicity of local anesthetic mixtures was essentially additive not synergistic.