Coinfection with Herpes Zoster Ophthalmicus and Oriental Eye Worm in a Rural Woman: The First Report of an Unusual Case

No abstract available.

Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma / 대한비뇨기과학회지

PURPOSE: We investigated the relationship between the expression of caveolin-1, using a tissue microarray (TMA), and the prognosis of patients with renal cell carcinoma (RCC). MATERIALS AND METHODS: TMA sections of formalin-fixed, paraffin-embedded tissues of RCC from 82 patients, who had undergone radical nephrectomy, were stained immunohistochemically with specific antibodies against caveolin-1. The caveolin-1 immunostaining was semi-quantitatively estimated based on intensity. The expression pattern of caveolin-1 was compared with the clinicopathological variables. RESULTS: The expression of caveolin-1 was significantly correlated with tumor size (p=0.002), TNM stage (p<0.001), T stage (p=0.001), M stage (p=0.004), grade (p=0.028) and metastasis (p<0.001), and was also significantly higher in clear cell than non-clear cell RCC (p<0.001). The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression (p=0.001). Univariate analyses were able to identify all variables, including caveolin-1 expression as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that TNM stage, M stage and grade were independent prognostic factors. Caveolin-1 expression was not an independent factor. CONCLUSIONS: The increased expression of caveolin-1 is associated with tumor size, stage, grade, metastasis and a worse prognosis in RCC, which suggests that caveolin-1 may be important in the progression of RCC.

Prognostic Value of Inverted Papilloma of the Urinary Tract / 대한비뇨기과학회지

PURPOSE: This study aimed to evaluate the tumor biologic behavior and prognostic value of inverted papilloma (IP) of the urinary tract. MATERIALS AND METHODS: Thirty-one cases (27 males and 4 females, mean age 55.2 years) of urinary IP that were treated at a single center were retrospectively reviewed. There were 21 cases with bladder IP only (group 1), 8 cases with bladder IP and transitional cell carcinoma (TCC) within a single neoplasm (group 2), and 2 cases with IP and TCC in a different location (group 3). The patient and tumor characteristics were analyzed. RESULTS: There was a male predominance with hematuria being the main presenting symptom in all groups. The most common macroscopic feature of IP was a polypoid lesion in group 1. The most common location of IP was bladder neck (57.1%) in group 1 and lateral bladder wall (75%) in group 2. The most common associated urologic disease was benign prostatic hyperplasia in group 1. Transurethral resection was performed in 30 cases (96.8%). There were no recurrences at a mean follow-up of 19.4 (3-68) months after surgery in 27 cases followed for 3 months or longer. CONCLUSIONS: One-third of urinary IP were associated with TCC within a single neoplasm or in a different location, and this suggests that IP has a malignant potential. However, because there was no recurrence in IP of the urinary tract, a surveillance protocol as frequent as the one suggested for urothelial cancer does not seem to be necessary.

Analysis of Heart Rate Variability in Patients BPH

PURPOSE: To characterize autonomic dysfunction in patients with benign prostatic hyperplasia(BPH), we measured heart rate variability(HRV) and analyzed them compared with those of normal population. MATERIALS AND METHODS: ECG signals were obtained from 11 male patients(mean age, 63.1 years) and 23 healthy male controls(mean age, 57.0 years) in resting state. We analyzed their parameters of HRV and compared them between groups. RESULTS: Time domain analysis including standard deviation of NN interval(SDNN), square root of mean of sum of squares of differences between adjacent NN intervals(RMSSD) in patients with BPH were not significantly different with those of controls. There were suggested evidence of decreased total power(TP), high frequency (HF) in patients with BPH(p<0.05) while no significant difference in other frequency domain such as very low frequency(VLF), low frequency(LF) and LF/HF ratio. CONCLUSION: This preliminary study shows that patients with BPH have different results on HRV study comparing to controls. With the exception of LF and LF/HF ratio, all parameters of HRV in patients with BPH lower than normal controls. TP, HF in patients with BPH significantly lower than that of normal controls. The decreased values of HRV study means that they may have some kinds of disease or imbalance in autonomic nervous system(ANS). So we suggest that HRV study may be a tool to describe the possibility of altered ANS activity in patients with BPH.

Primary Actinomycosis of the Urinary Bladder Associated with Intrauterine Contraceptive Device / 대한비뇨기과학회지

Actinomycosis is a chronic suppurative infectious disease usually caused by the anaerobic bacterium Actinomyces israelii. Pelvic actinomycosis is rare, and usually associated with the use of intrauterine contraceptive devices. Primary vesical actinomycosis is extremely rare. Herein, a case of a 42-year-old woman, who presented with bladder irritative symptoms and had a 13 year history of intrauterine device insertion, is reported. With the presumptive diagnosis of bladder tumor or abscess, partial cystectomy was performed. Pathological examination revealed a primary vesical actinomycosis.