ABSTRACT
Antecedentes. La parálisis cerebral tipo diplejía espática genera cambios en el sistema cardiovascular que afectan la capacidad aeróbica. La terapia acuática es una estrategia terapéutica óptima tanto para el manejo de la población como para el entrenamiento de la capacidad aeróbica, por las respuestas fisiológicas que genera y porque brinda la facilidad de generar mayores cargas al sistema cardiovascular con menores riesgos que en tierra. Objetivo. Identificar las características que debe tener una propuesta de intervención fisioterapéutica para el entrenamiento de la capacidad aérobica en niños y niñas entre los 8 y los 12 años, con parálisis cerebral tipo diplejía espástica, empleando la terapia acuática. Materiales y métodos. Se desarrolló un estudio de tipo descriptivo-propositivo, en el cual se formuló una propuesta de intervención basada en información recolectada a través de referencias bibliográficas. Resultados. Se presentan en forma de propuesta de intervención, describiendo en detalle las fases del entrenamiento de la capacidad aeróbica, mediante los principios del entrenamiento y la prescripción de ejercicio físico, teniendo en cuenta las respuestas fisiológicas ante la carga, así como las características propias de la población. Conclusión. La parálisis cerebral tipo diplejía espástica, genera cambios en la capacidad aeróbica; por esto, el fisioterapeuta debe incluirla en los procesos de rehabilitación como uno de sus objetivos. Para lograrlo, la terapia acuática es una modalidad de tratamiento óptima, puesto que genera mayor seguridad de movimiento y respuestas fisiológicas favorables en el sistema cardiovascular.
Background. The cerebral palsy is a condition that generates changes in the cardiovascular system affecting the aerobic capacity. Aquatic therapy is an optimal therapeutic strategy for the management of both the population and the aerobic capacity training because of the physiological responses generated and the ease of generating higher loads on the cardiovascular system with lower risk than on land. Objective. The aim of this research was to identify the characteristics of a physiotherapy intervention proposal for children aged 8 to 12 years-old with spastic diplegia cerebral palsy, using aquatic therapy for aerobic capacity training. Materials and methods. The research reflects a descriptive-proposal study, in which an intervention proposal was made based on information collected through references. Results. Results are presented in the form of intervention proposal that seeks to describe in detail the stages of aerobic training based on the principles of training and prescribing exercise, taking into account the physiological responses to the load and the characteristics of the population. Conclusion. The cerebral palsy caused changes in the aerobic capacity therefore it must be included in the physiotherapist rehabilitation processes as one of its main objectives. The findings indicate that aquatic therapy is an excellent treatment method for training aerobic capacity in this population, because of the greater security of movement and the favorable physiological responses that are generated in the cardiovascular system.
ABSTRACT
Angiogenesis is a complex multi-step process of neovascularization arising from preexisting blood vessels whose generation is regulated by pro- and anti-angiogenic factors. Both Trypanosoma cruzi calreticulin (TcCRT) and its human counterpart (HuCRT) are antiangiogenic. This is the first report where the TcCRT and HuCRT anti-angiogenic properties are compared in vivo. In the chick embryonic chorioallantoid membrane assay (CAM) and at equimolar concentrations, TcCRT displayed significantly higher antiangiogenic activities than its human counterpart. LPS had marginal effects at the concentrations present in the recombinant protein preparations and the TcCRT antiangiogenic effects were largely inhibited by specific polyclonal antibodies, thus, reinforcing the fact that the observed TcCRT effects can be attributed to the parasite-derived molecule and not to the endotoxin. The antiangiogenic TcCRT effects correlate with its anti-tumor in vivo effects, as recently shown in our laboratory.