ABSTRACT
In this study, we suggest analyzing the main transfusionnel incidents arisen during the activity of transfusion in the day hospital of the national center of bone-marrow transplant. It was a retrospective study over 11 years enlisting 200 patients all transfused at least once. They were distributed into 111 boys and 89 girls. Their average age was of 9 years [1-25 years]. We call incidental transfusionnel any unexpected or unwanted effect of transfusion origin. This incident is immediate when it arises during 8 days following the transfusion, it is delayed exceeded these deadlines. During these 11 years of activities our 200 patients received 22680 pockets of blood. The main transfusion indications were beta thalassemia major in 135 cases and sickle cell disease in 48 cases. Thirty five immediate incidents arose [17.5 per cent] [0.016 incidents / patient/ year]. Twenty eight delayed incidents were noted [14 per cent] [0.012 incidents / patient/ year]. The transfusions related incidents stay rare events. However their census and their compulsory declaration are indispensables to improve the transfusion security
ABSTRACT
Fetal/Neonatal alloimmune thrombocytopenia [FNAIT], resulting from maternal alloimmunisation against fetal platelet antigens, is a serious affection. The frequency has been estimated to be 1 out of 800-1000 live births. We report a new observation of alloimmune neonatal thrombocytopeni due to anti HPA-5b [Bra] antibodies. Case report: A male full term neonate presented at birth with a thrombocytopenia unexplained by usual causes of neonatal thrombocytopenia. Alloimmune neonatal thrombocytopenia was diagnosed by the determination of platelets and neonatal patelets antigens phenotypes HPA-5b [antiBra] antibodies in maternal sera, absent at delivery, were identified four months neonatal later. A favourable evolution was obtained after maternal washed platelet transfusion. Alloimmune thrombocytopenia is a seious affection, which exposs to intracranial haemorrhage. Difficulties in detemining the diagnosis should not delay therapy, depending on exclusion of other causes