ABSTRACT
Acute rejection is one of the most important complications after renal transplantation which influences transplant prognosis and survival. This study was conducted to determine the prognostic value of Th1/ Th2 cytokines in acute renal rejection [AR]. This was a cross-sectional study and included 60 kidney transplant recipients [40 male, mean age 38.82], who had received their transplants from live donors. Serum levels of Th-1 dependent cytokines [interleukin- [IL] 2 and interferon-gamma] and Th-2 dependent cytokines [IL-4, IL-10] were measured on the day before, 7th and 14th days post transplantation using ELISA. All the patients received Immunosupressive agents including cyclosporine, mychofenolate mofetile and prednisolon. Acute rejection was defined as a more than 50 percent rise in serum creatinin in the first 20 days after transplantation. Data were introduced into SPSS soft ware and analyzed by means of independent T-test. Among 60 patients, 40 were male. The mean age of the patients were 38.82 years. In our study we diagnosed twelve cases of AR [20% of the cases]. There was no significant relation between the serum levels of IL2, IL4, IL10 and IFN zeta in the patients with acute rejection of the transplant and those without. These data showed that there is no correlation between Th1/ Th2 serum cytokines profile and early AR episodes in kidney transplantation and these cytokines can not be used as prognostic factors in acute renal rejection