[Treatment of subjective peripheral tinnitus with Transcutaneous electrical stimulation]

Treatment of subjective idiopathic tinnitus is very difficult and many different treatment are available at present with different response rate. In this study, the effectiveness of transcutaneous electrical stimulation in subjective tinnitus was evaluated. 62 patients with subjective tinnitus were entered to this study. Transcutaneous electrical stimulation was applied weekly by dual channel TENS stimulator. 51.2% of patients have had good response to this treatment. All of these patients explained a tinnitus which was tolerable and there was not sleep disturbance at least for 6 months

[Evaluation of e-cadherin and its correlation with lymphatic metastasis and tumor grade in laryngeal SCC]

Lymphatic metastasis is a determining factor in treatment modality selection and prognosis of laryngeal cancer. It occurs because of separation of tumor cell from primary foci and deposition in lymphatic nodules which in turn occurs because of weakening of cell-cell adhesion. E-cadherin is a cellular adhesion molecule. Abnormal expression of this molecule may lead intercellular connection weakening and following metastasis. In this study we assess the correlation of abnormal expression of this molecule and metastasis. It is done as a prospective study on 47 proved laryngeal cancer. Initially, samples are divided into metastatic and non metastatic group. In next step, Immunohistochemistry was done to show E-cadherin expression. It was done as a blind study. In this study we use from a scoring system in order to convert qualitative data to semi quantitative ones. From total 47 cases, 21 case were metastatic and 26 cases were non metastatic. Nearly 70% had altered E-cadherin expression. We found significant statistical correlation between Abnormal expression of E-cadherin and tumor grade and metastasis P=0.000 and P=0.002, respectively. Also, tumor grade and metastasis had significant correlation. Abnormal expression of E-cadherin is a common finding among laryngeal cancers. It is directly related to metastasis and tumor grade. So, it can be used as predicting marker in order to choose more-aggressive treatment modality to improve prognosis and probably survival

[Treatment of the nose and paranasal sinusea cancers Omid hospital during 1365 - 75]

Maligment tumors of sinonasal tract are rare lesions. These tumors are diagnosed in late stage due to nonspecifications and symptoms the best treatment for nonepithelial tumors are combined [radical surgery and postoperative radiotherapy]. In this study 25 patient with sinonasal tumors are reviewed. The most important cause of treatment failure was late diagnosis and incomplete follow up due to uncooperative patients. The median DFS in the patients with malignant epithelial tumors who were treated with radical surgery was 48 months