Induction of mesenchynal neoplasms by DMBA implantation in deep lingual submucosa of male albino rats

45 male albino rats were used to study the effect of deep submucosal implantation of DMBA on lingual carcinogenesis. The results showed development of different mesenchymal neoplasm [fibroma, fibrosarcoma and leiomyosarcoma]. So, this method of implantation could not be used as an ideal animal model for production of single known neoplasm as had been investigated by many investigators before

Histological, histochemical and scanning electron microscopic studies on epidermoid carcinoma of the floor of the mouth in male albino rats

Thirty male albino rats were used in this study to investigate and explore the malignant changes occurring in the floor of the mouth. The histological and histochemical results showed that developing carcinoma was of poorly differentiated type in most cases, in addition SEM examination of the surface [20 weeks after scratching] showed definite surface changes in the experimental group [painted with DMBA]