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@#甲状腺癌是常见的内分泌恶性肿瘤，发病率逐年增加。深入了解甲状腺癌发生发展机制对提高诊断准确性、进行精准风险分层和实现个性化治疗至关重要。近年来，随着质谱相关技术的不断发展，基于不同标本类型（细胞、组织、血清和尿液）的多种蛋白质组学分析方法已被广泛应用于甲状腺癌的研究中，从阐明发病机制、诊断分型、预测预后和靶向治疗等方面积极地推动了甲状腺癌精准诊疗的发展。
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OBJECTIVE@#To analyze how governments, hospitals and information technology(IT) companies use Internet technology to provide online health services during the early stage of corona virus disease 2019 (COVID-19) epidemic in January 2020 in China, and then provide suggestions and coping strategies for the later stage and post-epidemic time.@*METHODS@#We searched for information on ehealth services related to the outbreak of COVID-19 in China. The sources of information were mainstream search engines such as Baidu and the popular interactive social platforms such as Webchat. The keywords were "Internet+pneumonia", "Internet clinic", "pneumonia online clinic" and so on. The time of information was from January 20 to February 3, 2020. The key information was extracted and encoded by two persons back-to-back. The coding information included: name of organization provider, launching time, location of provider, service items, user, health workers engaging in the service, and so on. The coded information was entered and analyzed with SPSS 24.0 and Excel.@*RESULTS@#There were totally 57 projects launched by local governments, hospitals and IT companies. Most of them were launched from January 24th to 27th, the hospital and government projects services regionally, especially in eastern provinces. In this study, 90.48% of the enterprises and 100.00% of the hospitals had online fever clinic and consultation services for COVID-19, 66.67% of the enterprises and 37.04% of the hospitals serviced derivative health problems. Only a few projects provided tele-medical consultation. There were individual projects that provided online health management for home quarantine people. Physicians were the main force of various projects. In some hospital projects, there were also nurses, pharmacists and professional technicians to provide featured consultation.@*CONCLUSION@#Ehealth is useful and helpful for the health care system to rapidly cope with health demand during instantaneous and post epidemic time. Regional distribution of ehealth is unbalanced. There are institutional and technical feasibilities for the emergency application of Internet technology. However, community health centers seldom provide ehealth or connect with tertiary hospitals with Internet. Therefore, all kinds of providers within healthcare system should promote emergence ehealth. Tele-medical diagnosis and referral should be developed by local governments during COVID-19. The application of "Internet+medical treatment" in community medical institutions and synergy among various institutions should be promoted.
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Humans , Betacoronavirus , COVID-19 , China , Coronavirus Infections , Pandemics , Pneumonia, Viral , SARS-CoV-2 , TelemedicineABSTRACT
@#AIM: To observe the visual quality after segmental Refractive multifocal intraocular lens(IOL)implantation.<p>METHODS: Totally 50 cases(83 eyes)of cataract patients who receiving phacoemulsification and IOL implantation in our hospital from June 2016 to February 2017 were selected as the study object. Based on the IOL types, the patients were divided into two groups: 22 cases(37 eyes)in observation group implanted segmental refractive multifocal IOL, 28 cases(46 eyes)in control group implanted monofocal IOL. Three months after surgery, the uncorrected visual acuity was recorded. A double-pass optical quality analysis system(OQAS II)was used to evaluate the visual quality. The near spectacle independence, satisfaction, and symptoms of visual disturbance were assessed by a questionnaire.<p>RESULTS: Three months after surgery, there were no statistical differences in uncorrected distance visual acuity(UCDVA)between the observation group and control group(<i>P</i>=0.273). The uncorrected intermediate visual acuity(UCIVA)and uncorrected near acuity(UCNVA)of observation group was better than control group(<i>P</i><0.05). There were no statistical differences in MTF cutoff; contrast visual acuity between the groups. The OSI in the observation and control groups was 2.64±0.68 and 1.52±0.47, respectively; objective amplitude of accommodation was(2.91±0.71)D and(1.32±0.41)D, respectively; near spectacle independence was 91% and 7%, respectively. There were statistical differences between the groups(<i>P</i><0.05). There were no statistical differences between the groups for visual disturbances(glare, ghosting)and satisfaction(<i>P</i>>0.05).<p>CONCLUSION: Segmental refractive multifocal intraocular lens provides wider objective amplitude of accommodation and good overall visual acuity, reduces spectacle dependency and provides high patient satisfaction.
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@# Tumor is a complex systemic disease, involving abnormalities at multiple levels, such as DNA, RNA, protein and metabolite. According to the central rule, the derived omics methods are genomics, transcriptomics, proteomics and metabonomics. In the past few decades, there have been remarkable achievements in the single omics study of tumor, but the exact mechanism of tumor development is still unclear. In order to reveal the process of tumorigenesis and development in a more systematic way, the research of multiomics came into being, which promoted the transformation of tumor research paradigm from single parameter model to multi parameter system model. The integration of multi-omics methods is expected to clarify the mechanism of tumor occurrence and development, find biomarkers with diagnostic, prognostic and predictive performance, explore new treatment targets, and finally achieve predictive, preventive, and personalized medicine (PPPM). This paper reviews the research methods and progress of different omics techniques in tumor research, especially emphasizes the importance and scientific value of the integration of multiple omics techniques in tumor research and clinical related results.
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AIM: To evaluate the clinical results of capsular tension ring (CTR) implantation in phacoemulsification for eyes with congenital lens subluxation.METHODS: This study comprised 18 patients (31 eyes) with congenital ectopia lentis.All patients received phacoemulsification with CTR and intraocular lens (IOL) implantation.Visual acuity before and after surgery were examined.IOL decentration were measured with Image-Pro Plus image processing software.The complications were also recorded preoperatively and postoperatively.RESULTS: Uncorrected vision of all eyes increased after surgery, and all cases had different degree of IOL decentration after surgery.Two eyes received CTR scleral fixation 3mo after surgery because the IOL decentration aggravated during the follow-up period.CONCLUSION: Phacoemulsification with CTR and IOL implantation is effective and safe for congenital lens subluxation.The implantation of CTR increase the stability of the capsular bag, improve the safety of surgery, and maintain the right position of IOL.CTR scleral fixation is a effective supplement for progressive cases.