ABSTRACT
The use of tagged donor cells introduces many other factors, both extra and intra-corpuscular, which may invalidate the results of the recipients own survival time. Questions of incompatibilities and the danger of the transmission of serum jaundice also attend the use of the above methods. (Author)
ABSTRACT
The total circulating red blood cells, or the so-called cell mass, in human has been determined by a variety of methods using different red cell tags. Prominent among these are the hemoglobin precursors, the use of which has been based on the assumption that since they are integral parts of the red blood cells, they should be the tags of choice in the study of human erythrocytes. (Author)
ABSTRACT
The in vitro metabolism of glucose by the anterior pituitary was studied in states of varied glandular activity. No significant differences were found in the glucose assimilation of the anterior pituitary glands from rats in the different stages of the estrus cycle, nor was there any alteration in the carbon dioxide evolution, lactic acid formation, lipogenesis from glucose and glycogenesis. However, when rats were ovariectomized or administered hypothalamic extracts prior to sacrifice, the anterior pituitaries manifested differential disposition of the assimilated glucose. Ovariectomy produced a progressive decline in carbon dioxide formation and a progressive increase in lactic acid formation. Administration of hypothalamic extract similarly decreased carbon dioxide formation although lactate formation was unaltered from controls, Lipogenesis and glycogenesis were unaffected. When marked changes are experimentally produced in a given cell population, detectable changes are thus manifested in the glucose metabolism of the anterior pituitary. Conclusions as to the relationship of this metabolic alteration to pituitary hormogenesis are, however, held tentative and speculative for the moment. (Summary)