ABSTRACT
Objective @#To explore the mediating effect of sleep quality on mobile phone dependence and loneliness in university students, so as to provide evidence for prevention and intervention of mobile phone dependence.@*Methods @#A survey was conducted from December 2019 and January 2020 among the students of Guangzhou Medical University. The general information questionnaire, mobile phone dependence index scale, UCLA loneliness scale and Pittsburgh sleep quality index scale were used to analyze the mediating effects of sleep quality on mobile phone dependence and loneliness. @*Results @#A total of 575 questionnaires were distributed and 573 valid ones were collected, with an efficiency of 99.65%. The detection rate of 115 students with mobile phone dependence was 20.07%, and that of 203 students with sleep quality problems was 35.43%. The students scored ( 48.03±6.07 ) points in loneliness, and 405 of them had high level. Mobile phone dependence was positively correlated with loneliness and sleep quality ( r=0.299, 0.385, both P<0.05 ); loneliness was positively correlated with sleep quality ( r=0.553, P<0.05 ). Mobile phone dependence and sleep quality both could positively predict loneliness, mobile phone dependence could positively predict sleep quality, and sleep quality and gender had a significant interaction effect on loneliness ( all P<0.05 ). The mediating effect value of sleep quality on mobile phone dependence and loneliness was 0.290 ( 95%CI: 0.186-0.400 ) in males and 0.131 ( 95%CI: 0.084-0.187 ) in females.@*Conclusion@#Sleep quality has a mediating effect on mobile phone dependence and loneliness among university students. Male students are susceptible to the negative effects of mobile phone dependence.
ABSTRACT
Objective@#To explore the relationship between attitudes towards disability and depression in hearing impaired college students,and to provide a basis for the mental health development of disabled college students.@*Methods@#A six-month two stage longitudinal follow-up study was conducted among 325 hearing impaired college students in a college of special education in Jilin Province, by using the World Health Organization attitudes towards disabilitys Scales and the Self-rating Depression Scale.@*Results@#The results of correlation analysis showed that disability attitudes was negatively correlated with depression at both time points(r=-0.39，-0.24，P<0.01); The results of cross lag regression analysis showed that T1 attitudes towards disability had a negative predictive effect on T2 depression(β=-0.30，P<0.01), while T1 depression had no significant predictive effect on T2 attitudes towards disability (β=-0.02，P=0.78). There was no significant gender difference in the interaction between attitudes towards disability and depression in hearing impaired college students(Δχ2=6.94，Δdf=8，P=0.54).@*Conclusion@#Attitudes towards disability of hearing impaired college students is closely related to depression,disability attitudes can negatively predict depression, and there is no significant gender difference.
ABSTRACT
This study was conducted to determine whether exposure to particulate matter 2.5 (PM2.5) affects the immune tolerance ofneonatal mice via the regulation of PD-L1 expression. One-week-old BALB/c mice were exposed to PM2.5 for 8 days.From day 8 to day 18, the mice were treated with 5 lg house dust mite (HDM) (i. n.) every two days. Adenovirus-carriedPD-L1 overexpression vectors were infected into mice via nasal inhalation 6 days after exposure to PM2.5. Airway hyperresponsiveness (AHR) was examined in mice 19 days after exposure to PM2.5, and the related parameters of airwayinflammation were studied on day 22. Co-exposure to PM2.5 and HDM reduced PD-L1 expression but greatly increasedinfiltration of inflammatory cells, which was reversed by PD-L1 overexpression. Co-exposure to PM2.5 and HDM alsoelevated serum IL-4, IL-5 and IL-13 levels and reduced TGF-b level. Exposure to PM2.5 alone slightly increased thenumbers of dendritic cells (DCs) but reduced the numbers of antigen-presenting cells expressing PD-L1 and Treg cells.Therefore, early exposure to PM2.5 reduced PD-L1 expression in the lungs of neonatal mice, which interfered with immunetolerance establishment and subsequently resulted in allergic airway inflammation
ABSTRACT
The theory of channels and collaterals is a very important "substance" prop for the basic theories of TCM. After component model of substances of channels and collaterals is raised, according to the principle, structure and function are dialectical unity, the author finds in deeply research on a great number of completed experimental investigations of corresponding anatomic position of channels and collaterals and similar physiology at home and abroad that the difficult to understand TCM concepts such as "interdependence between yin and yang", "defensive energy" all could be displayed by the substance of body liquid showing liquid crystalline state during living of channels and collaterals.