ABSTRACT
This paper is to report the polymorphism of raw materials of clopidogrel bisulfate at home and abroad. By the analysis of Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (p-XRD), samples are roughly classified into two groups, except one patent material. And the differential scanning calorimeter (DSC) examination showed more detailed information for these materials. The results of the study could provide comprehensive basis for the quality evaluation of clopidogrel bisulfate.
Subject(s)
Calorimetry, Differential Scanning , Crystallization , Evaluation Studies as Topic , Platelet Aggregation Inhibitors , Chemistry , Spectroscopy, Fourier Transform Infrared , Ticlopidine , Chemistry , X-Ray DiffractionABSTRACT
<p><b>OBJECTIVE</b>To establish a method for analyzing amorphous organic compound components of space Platycodon grandflorum rapidly.</p><p><b>METHOD</b>FTIR was applied for measuring and comparing P. grandflorum of comparison group,the ground group and the 4" generation of space group.</p><p><b>RESULT</b>Several active components (platycodin, polysaccharide etc.) contents of space group are increased obviously.</p><p><b>CONCLUSION</b>The major components and the structures remained inextenso,and the effictive component contents are enhanced in the space P. grandiflorum. FTIR is a fast method to analyze the changes of amorphous organic compound components of the space traditional Chinese medicines.</p>