ABSTRACT
A retrospective, nonrandomized, single-center clinical study was designed to evaluate the outcomes of corneal collagen crosslinking [CXL] for progressive keratoconus in Iranian patients 12 months after CXL. This study was carried out at Navid Didegan Eye Center, a private clinic, Mashhad, Iran. Ninety-two eyes of 53 subjects with progressive keratoconus were evaluated in this study. All eyes completed 1-year follow-up. The outcome measures were uncorrected visual acuity [UCVA], best spectacle-corrected visual acuity [BSCVA], sphere and cylinder refraction, keratometry, and corneal thickness. Comparison of baseline and 1-year postoperative data is reported in this study. The Wilcoxon signed-ranked and Student's t-tests were used for statistical analyses. P < 0.05 was statistically significant. The mean age was 21.5 +/- 3.4 years [range, 16 -30 years]. Thirty-one [58.5%] of the subjects were men and 22 [41.5%] were women. Mean baseline UCVA and BSCVA were 0.61 +/- 0.31 and 0.06 +/- 0.12 logarithm of minimal angle of resolution [logMAR], respectively. One year postoperatively UCVA was 0.31 +/- 0.25 logMAR and BSCVA was 0.0 +/- 0.01 logMAR. UCVA and BSCVA were statistically higher postoperatively [P < 0.001, both parameters]. The mean astigmatism decreased by 0.78 +/- 1.49 diopter [D] with significant variation during the follow-up period [P < 0.001]. Mean baseline simulated keratometry [SIM K] was 46.94 +/- 2.37 D and decreased to 46.0 +/- 2.33 D on year postoperatively [P < 0.001]. Corneal CXL seems to be efficient in stabilization of progressive keratoconus progression in Iranian patients at 1 year of follow up