ABSTRACT
We report here a 2.5-year-old male child with community-acquired Pseudomonal sepsis showing the characteristic lesions of ecthyma gangrenosum. The child had development of gangrenous changes of the nose and face - the 'cancrum oris' or 'Noma'. We highlight the possible association of Pseudomonas sepsis and Noma, with malnutrition playing a central role in causing both the diseases.
Subject(s)
Child Nutrition Disorders/complications , Child, Preschool , Humans , Male , Noma/complications , Pseudomonas Infections/complications , Sepsis/complicationsABSTRACT
A case of mixed infection due to Leptospira and Dengue in a two and a half-year-old girl with pyrexia is reported. Early detection and institution of appropriate therapy is crucial and lifesaving.
Subject(s)
Age Distribution , Child , Child, Preschool , Enzyme-Linked Immunosorbent Assay , Female , HIV Infections/diagnosis , HIV Seropositivity/diagnosis , Hospitalization , Humans , Incidence , India/epidemiology , Infant , Male , Mass Screening/methods , Prospective Studies , Registries , Risk Factors , Sex Distribution , Urban PopulationABSTRACT
OBJECTIVES: To evaluate efficacy of polymerase chain reaction (PCR), using the insertion sequence IS6110 as target for DNA, to detect Mycobacterium tuberculosis in body fluids of children with suspected tuberculosis (TB). SETTING: Hospitalized patients. METHODS: A comparison of PCR on body fluids, Acid Fast Bacilli staining (AFB), mycobacterial culture and clinical features, with special emphasis on central nervous system (CNS) TB was done over 18 month period. A total of 80 children were evaluated, 41 with probable TB disease and 39 controls. Cases were defined by specific clinical criteria. Controls included patients free of clinical TB. PCR was done on the clinical specimens and compared with clinical findings, radiological features, Mantoux (Mx) testing, AFB staining and culture on Lowenstein-Jensen (LJ) medium. RESULTS: Sensitivity of PCR in CSF samples was 100%, in gastric aspirate samples was 20% and in pleural fluid samples was 100%. CONCLUSION: PCR technique may become a valuable diagnostic tool for the diagnosis of tuberculosis in children especially in CNS TB.
Subject(s)
Base Sequence , Case-Control Studies , Child , Child, Preschool , DNA, Bacterial/analysis , Female , Humans , India , Infant , Male , Molecular Sequence Data , Mycobacterium tuberculosis/isolation & purification , Polymerase Chain Reaction/methods , Reference Values , Sensitivity and Specificity , Tuberculosis/diagnosisABSTRACT
We report three sibs with mild autosomal recessive variety of osteopetrosis. The prominent clinical features were short stature, malocclusion of teeth, hepatosplenomegaly and a typical facial appearance. The only atypical features were microcephaly, a normal upper segment to lower segment ratio and a normal arm span.
Subject(s)
Child , Child, Preschool , Female , Genes, Recessive/genetics , Genetic Diseases, Inborn/genetics , Humans , Infant , Osteopetrosis/genetics , PedigreeABSTRACT
The airways in infants and children are anatomically different from adults, thus predisposing them to more acute upper airway obstruction. The causes of upper airway obstruction may be infective or non-infective. The presence of dysphonia, dysphagia, abnormal respiratory pattern, cough and abnormal posture suggests upper airway obstruction. The general management consist of supportive care with minimal invasive procedures. The specific treatment depends on the causes and is discussed in text.
Subject(s)
Adolescent , Adult , Age Factors , Airway Obstruction/diagnosis , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Infant , MaleABSTRACT
An eleven year old boy presented with sudden onset right-sided hemiplegia and ipsilateral lower facial weakness. Two-dimensional echo revealed the diagnosis of idiopathic dilated cardiomyopathy with multiple intracardiac clots. MRI scan of head showed infarctions in the area of caudate nuclei, putamen, brain stem and cerebellum. On anticoagulation therapy, all thrombi, except one, disappeared. The child died 2.5 months later due to resistant cardiac failure.
Subject(s)
Anticoagulants/therapeutic use , Cardiomyopathy, Dilated/complications , Cerebral Infarction/diagnosis , Child , Fatal Outcome , Humans , Intracranial Embolism and Thrombosis/diagnosis , Magnetic Resonance Imaging , MaleSubject(s)
Age of Onset , Child , Child Abuse, Sexual , Female , Humans , Keratitis/etiology , Osteomyelitis/etiology , Shoulder Joint , Syphilis, Congenital/complicationsABSTRACT
A 2 1/2 month old male child was admitted with loose motions and mild dehydration. He was full term normal delivery, born of a non-consanguinous marriage. On examination, he had trigonocephaly; anteverted nostrils, long philtrum and hypoplastic supraorbital ridges. X-ray showed sutural separation. Karyotyping confirmed deletion of short arm of chromosome 9 distal to band p22.
Subject(s)
Child, Preschool , Chromosome Deletion , Chromosomes, Human, Pair 9 , Craniofacial Dysostosis/etiology , Humans , Male , Skull/abnormalities , SyndromeSubject(s)
Biopsy , Child , Child, Preschool , Diagnosis, Differential , Diagnostic Imaging , Female , Humans , Lung/pathology , Lung Diseases, Parasitic/diagnosis , Male , Pulmonary Eosinophilia/etiologySubject(s)
Ambulatory Care , Child , Humans , Lung Diseases/diagnosis , Pediatrics , Reference Values , Respiratory Function TestsSubject(s)
Anemia, Hemolytic, Autoimmune/classification , Child , Female , Humans , Prednisolone/therapeutic useABSTRACT
A case of tetralogy of fallot with congenital intermittent atrioventricular dissociation is reported. A review of standard postgraduate books of cardiology fails to describe this condition, thus showing its extreme rarity. The therapeutic dilemma in treating such a case is also discussed.
Subject(s)
Child , Electrocardiography , Female , Heart Block/congenital , Humans , Tetralogy of Fallot/complicationsABSTRACT
A 6 1/2 year old female child with congenital lipodystrophy is being presented. The noteworthy feature in this case was the defective leucocyte function and its association with tuberculous pericardial effusion.