ABSTRACT
Background: The offspring of women with gestational diabetes mellitus [GDM] are prone to macrosomia. However, birth weight is difficult to be correctly estimated by ultrasound because of fetal asymmetric growth characteristics. This study aimed at investigating the correlations between fetal hemodynamics, fetal growth indices in late pregnancy and birth weight in GDM
Methods: A total of 180 women with GDM and 180 normal controls [NC] with singleton gestation and presented between 38-40 weeks gestation were enrolled in this study. Fetal hemodynamic indices, including the systolic/diastolic ratio [S/D], resistance index [RI], pulsatility index [PI] of umbilical artery [UA], middle cerebral artery [MCA], and renal artery [RA], were collected. Fetal growth indices, including biparietal diameter [BPD], head circumference [HC], abdominal circumference [AC], and femur length [FL], were also measured by ultrasound. Birth weight, mode of delivery and need for Neonatal ICU admission data were collected
Results: The independent samples t-test showed that BPD, HC, AC and FL were larger in GDM than in NC [P < 0.05]. Birth weight was higher in GDM than in NC [P < 0.001]. Among all included women, there was a highly statistically insignificant difference between GDM and NC groups as regard all ultrasound indices including UA_S/D, UA_RI, UA_PI, MCA_S/D, MCA_RI, MCA_PI, RA_S/D, RA_RI and RA_PI [P>0.05]. Pearson's correlation analysis showed in GDM group that there was a highly statistically significant negative correlation between birth weight and the following ultrasound indices: [UA_RI, UA_S/D, UA_PI, MCA_RI and MCA_PI] and that there was a statistically significant positive correlation between birth weight and RA_RI [P<0.01] [r = -0.273, -0.453, -0.537, -0.237, -0.265 and 0.169 respectively, P < 0.05], but As regard NC group there was a highly statistically significant negative correlation between birth weight and the following ultrasound indices: [UA_S/D, UA_RI, UA_PI and MCA_PI] [r = 0.148, -0.360, -0.252 and -0.184 respectively, P < 0.05] but no correlation was found with any of renal artery indices [P > 0.05]
Conclusions: Fetal hemodynamic indices in late pregnancy might be helpful for estimating newborn birth weight in women with GDM
ABSTRACT
Background: Herpes simplex viruses [HSVs] are responsible for a variety of human diseases. Although lesions are usually self-limited, severe manifestations can occur, particularly in compromised hosts. Effectiveness of therapy for such infections relies upon rapid administration of appropriate antivirals which in turn creates the need to establish a prompt diagnosis and necessitates diagnostic testing that is rapid, sensitive and affordable especially for laboratories in developing countries. The specificity of tests is also crucial, since clinical manifestations of HSV are relatively nonspecific and overlap other potentially severe infections
Objectives: This study aimed at comparing the performance of two relatively affordable diagnostic assays; conventional PCR and tissue culture; in the detection of HSV in different clinical specimens
Methodology: Seventy participants were included and divided into two groups. Group I: comprised 50 patients with suspected herpetic lesions. Group II: comprised 20 subjects without any herpetic clinical manifestations. Samples from participants were tested for HSV pol gene by conventional PCR. Tissue culture was performed by inoculating the samples on Vero cell line
Results: Conventional PCR showed perfect agreement with the gold standard [kappa= 1] with sensitivity, specificity, and accuracy of 100%.Tissue culture assay detected 15 [21.4%] of all positive cases showing substantial agreement with the gold standard [kappa= 0.632] with sensitivity, specificity and accuracy of 57.7%, 100% and 84.29%, respectively
Conclusion: Though tissue culture has its own advantages, conventional PCR could serve as a gold standard for the diagnosis of HSV infection
ABSTRACT
Background: Dysfunctional uterine bleeding [DUB] is one of the commonest condition for which patient seeks out medical consultation. The prevalence increases with the increase of age peaking before menopause
Objective: The aim of this work is to evaluate the effect of this new form of levonorgestrel-releasing IUD on the treatment of patients with abnormal uterine bleeding
Subjects and methods: A prospective age-specific comparative analysis of 61 peri-menopausal women presented with dysfunctional uterine bleeding who constituted the study group. They underwent hysteroscopy and endometrial sampling during an 18 months period from June 2014 to January 2016 at Ain Shams University Materity Hospital. Prior to metraplant-E application, all the patients in this study were in the age of 25-58 years old
Results: The role of Metraplant-E in the treatment of abnormal uterine bleeding [AUB] was evaluated. Sixty-one women with failed attempt[s] of medical treatment unwilling or unfit for hysterectomy were treated with Metaplant-E. Menstrual blood loss was assessed by pictoral bleeding assessment chart [PBAC], bleeding index [B.I] and total bleeding score [T.B.S/month]. The bleeding patterns in the form of the mean menstrual blood loss estimated by bleeding index and the mean menstrual loss estimated by the total bleeding score/month and PBAC decreased significantly [p = 0.001]. The quality of life scale [Likert scale] improved significantly [p = 0.001]. All 15 cases who had endometrial sampling demonstrated progestational effect on histo-pathological examination
Conclusion: Metraplant-E was found to be effective in managing dysfunctional menorrhagia on both clinical and histopathological levels