ABSTRACT
Introduction: Adiponectin is a protein hormone secreted exclusive by adipocytes that regulate the metabolism of lipids and glucose. It has antidiabetic, antiatherogenic and anti-inflammatory properties
Objective: To asses adiponectin serum levels in adolescent boys with type development, body mass index [BMI], glycemic control and insulin dosage
Research design and methods: A case-control study was carried out on 45 adolescent boys with T1DM aged [12-18] years and 37 healthy control boys of similar age. Each of the cases and control groups were divided into four subgroups according to their Tanner stage .They were subjected to full history, reviewing medical records, auxology and pubertal stage assessment. Serum total adiponectin level was determined by ELISA technique in addition to giycatedhaemoglobin [HbAlc] and fasting blood glucose
Results: Mean adiponectin serum level [ +/- SD] was significantly higher in T1DM boys compared to healthy control group [12.93 +/- 5.24micro g/mlversus 8.91 +/- 3.21 micro g/ ml] [P<0.001] . Such higher serum levels of adiponectin were detected mainly at Tanner stage 2 [16.571 4.60 micro g/ mlvs 11.88 +/- 3.39 micro g/ ml] [P= 0.025] and Tanner stage 3 [12.77 +/- 3.71 micro g/ ml vs.6.59i 1.54 micro g ml] [P= 0.002]. Adiponectin level decreased significantly during pubertal development in control group and T1DM group. Adiponectin level was significantly higher in diabetic-poor controlled group than diabetic good-controlled group. Adiponectin was negatively correlated with pubertal stage, age, intermediate/ long acting insulin dose and positively correlated to HbAlc in diabetic group. In control group adiponectin levels were negatively correlated with pubertal stage and BMI
Conclusion: Adiponectin serum levels in adolescent boys with type 1 diabetes were significantly higher than control mainly at early puberty. It decreased significantly during pubertal development and was' strongly positively related to glycemic control