ABSTRACT
The root extracts of Ichnocarpus fructensces (L) R.Br is been scientifically proved for its analgesic and anti-inflammatory activity and the present study was under taken to evaluate the topical preparation of methanolic extracts of root of Icthnocarpus fructensces for analgesic and anti-inflammatory activities. Four different concentrations of the root extract was made in to a topical preparation i.e IF 1%, IF 2%, IF 4% and IF 6% with the help of a cream base containing cetyl alcohol, white petrolatum ,mineral oil, carbapol ,tween 80, water and Propylene glycol. All the four formulations along with cream base were screened for their analgesic and anti-inflammatory activities using formaline induced paw licking test and carrageenan induce paw edema models respectively. In analgesic activity, the IF 6 % has showed significant analgesic effect by decreasing the no. of paw lickings in formalin induced rat paw licking test; In antiinflammatory activity the IF 1%, IF 2% has showed slight inhibition and IF 4%, IF 6% have showed significant inhibition of carrageenan induced rat paw edema compared to control group in which only cream base was used. The anti-inflammatory activity of IF 4 % and IF 6% were comparable with 0.5 % piroxicam gel which was used as standard and analgesic activity of the IF 6% was comparable with standard formulation 30% Methyl salicylate ointment.
ABSTRACT
Desmostachya bipinnata root has been used in the Indian traditional system of medicine for treatment of diarrhoea and dysentery. The antidiarrhoeal effect of both alcoholic and aqueous extracts of the roots of Desmostachya bipinnata were studied in rats against castor oil induced diarrhoea and charcoal meal test at the doses of 200 and 400 mg/kg body weight. The alcoholic extract and to a lesser extent aqueous extract significantly reduced the weight of the faces and decreased the propulsion of charcoal meal through the gastrointestinal tract. The phytochemical screening of the extracts showed the presence of alkaloids, glycosides, flavonoids, tannins, phytosterol, terpenoids, polyphenolics, protein and carbohydrates. These results may support the fact that this plant is used traditionally to cure diarrhoea.
La raíz de Desmostachya bipinnata ha sido utilizada en el sistema tradicional de medicina Hindú para el tratamiento de diarrea y disentería. El efecto antidiarreico de los extractos alcohólicos y acuosos de los extractos de la raíz de Desmostachya bipinnata fueron estudiados en ratas, utilizando la diarrea inducida por aceite de castor y el ensayo de la prueba por carbón en dosis de 200 y 400 mg/kg de peso corporal. El extracto alcohólico y en menor grado, el extracto acuoso, redujeron significativamente la propulsión de carbón a través del tracto gastrointestinal. El análisis de los extractos mostrarón la presencia de alcaloides, glicósidos, flavonoides, taninos, fitoesterol, terpenoides, polifenoles, proteínas y carbohidratos. Estos resultados pueden apoyar el hecho de que esta planta sea usada tradicionalmente para curar la diarrea.
Subject(s)
Animals , Rats , Antidiarrheals/pharmacology , Diarrhea/drug therapy , Ethanol/pharmacology , Plant Extracts/pharmacology , Poaceae/chemistry , Plant Roots/chemistry , Castor Oil , Diarrhea/chemically induced , Gastrointestinal Motility , Rats, WistarABSTRACT
Portulaca oleracea Linn, belongs to family Portulaceae and is a widely distributed weed. It has been used as a folk medicine in many countries as diuretics, febrifuge, antiseptic, antispasmodic and vermifuge. This paper deals with the microscopic study of leaf; stem and root of Portulaca oleracea, along with the physico-chemical and preliminary phytochemical analyses that were also studied.
Portulaca oleracea Linn, pertence à família Portulaceae e é uma erva daninha amplamente distribuída. Ela tem sido utilizada como remédio popular em muitos países como diurético, febrífugo, anti-séptico, antiespasmódico e vermífugo. Este artigo aborda o estudo microscópico da folha, caule e raiz de Portulaca oleracea, juntamente com as análises físico-química e fitoquímica preliminar que foram também estudadas.