Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add filters








Language
Year range
1.
Article in English | IMSEAR | ID: sea-151582

ABSTRACT

Karpoora Cinthamani Mathirai (KCM) is a traditional Siddha medicinal preparation using to treat Arthritis associated with fever narrated in the text Anubhoga Vaithiya Navaneetham. This formulation has the detoxified ingredients such as Hydrargyrum subchloride and Croton tiglium seeds. The aim was to establish a fingerprint to ensure the quality and safety of KCM. Physicochemical characterization of KCM was carried out using qualitative biochemical analysis and modern techniques such as Fourier transform infra-red spectroscopy, inductively coupled plasma analysis and scanning electron microscopy. Physical evaluation revealed that KCM is a light green colour pill, neutral nature and having solubility in water and HCl with stabilized particle size distribution of 3μ. A clearly identifiable fraction of KCM particles were below 50 nm. The presence of nano sized particles and functional groups carboxylic acids and nitrocompounds in KCM might impart the therapeutic property. Trace elemental analysis of KCM revealed that heavy metals like arsenic, cadmium, mercury and lead were below the deduction limit. Further, elemental analysis of KCM revealed the presence of minerals like calcium, iron, potassium, sodium, and phosphorus under acceptable limits at the prescribed dose of KCM.

2.
Article in English | IMSEAR | ID: sea-151084

ABSTRACT

Sphaeranthus amaranthoides Burm belonging to the family Asteraceae is a rejuvenator herb of Siddha system having Tamil name ‘Sivakaranthai’. The present studies deals with a detailed pharmacological including pharmacognostical study particularly on leaf and infloresence of Sphaeranthus amaranthoides. The morphological characters of leaf and inflorescence observed by double staining. It revealed the stomatal index of lower surface with 42-48 and upper surface with 30-36/mm2 and presence of leaf resin canals. Inflorescences are cone shaped and its axis is siphonate. Sivakaranthai leaf powder (SLP) subjected to quality control test and by phytoconstituents estimation, appreciable presence of calcium, ferrous, tannin, proteins and phenols known. The results of elemental concentration level indicated the presence of toxic metals within the tolerance level. In vitro antibacterial activity evaluation confirmed the good anti-microbial activity at the dilution of 50 μl/disc against bacterial strain such as Streptococcus mutans, Staphylococcus aureus, Escherchia coli Klebsiella pneumonia, Pseudomonas aeruginosa. Rats found safe up to a maximum dose of 2000mg/kg body weight in acute toxicity study following OECD 423 guidelines. The analgesic and anti-inflammation activities evaluation were done by tail flick hot water immersion method and by Carrageenan induced acute hind paw oedema method on Wistar albino rats, respectively. The SLP has shown very weak analgesic and moderate antiinflammatory action rather than standard Indomethacin and no adverse effects produced. In the light of above results, it concluded that Sphaeranthus amaranthoides might use in any suitable formulation in which anti-microbial property and micronutrients needed.

3.
Article in English | IMSEAR | ID: sea-150869

ABSTRACT

Background: Vediuppu Chendhuram (VC) is a traditional Siddha mineral formulation applied to treat Urinary tract dysfunction such as burning micturation and retention of urine. It is synthesized through special oxidation of Vediuppu as narrated in the text Anubhoga Vaithiya Navaneetham. Physicochemical characterization of VC has been carried out using qualitative compound analysis and modern techniques such as Fourier transform infra-red spectroscopy, inductively coupled plasma analysis and scanning electron microscopy. Such study reveals the presence of heavy metals like arsenic, cadmium, mercury and lead are present below the detection limit and the presence of sodium, potassium, sulphur, phosphorus and calcium under acceptable limits. The primary objective of this work is to validate the safety of VC through animal model. Methods: The raw Vediuppu are procured from country drug store at Nagercoil, Tamilnadu and purified by the traditional procedure by soaking in Cow’s urine until it dried. The test drug VC is prepared by the process of Pudam (Oxidation) described in Anuboga Vaithiya Navaneetham 3rd part, pg no. 76-77. The safety profile is evaluated by doing acute oral toxicity and repeated oral toxicity studies under OECD guidelines on Albino wistar rats. Results: Animals were found to be safe upto 300mg/kg body weight in acute oral toxicity study. Repeated toxicity study of VC has revealed that upto 200mg/kg body weight; all the treated animals have survived throughout the dosing period of 28 days. But at the dose of 400mg/kg, exhibits mortality on 21st day of treatment. No significant changes in the body weight, food and water intake have been observed. Complete urine, haematology, biochemical analyses, gross necropsy and histopathological examination at the end of treatment did not reveal any abnormalities. Conclusion: Vediuppu Chendhuram is the safest drug under intended human adult dosages (520 mg – 1040 mg) as illustrated in the literature.

SELECTION OF CITATIONS
SEARCH DETAIL