ABSTRACT
Background: Diabetic nephropathy (DN) is one of the majormicrovascular complications of diabetes and it is defined as arise in the urinary albumin excretion rate and abnormal renalfunction. Some patient develop advanced renal impairmentwith normal urinary albumin level thus albuminuria is not theperfect marker for the early detection of Diabetic nephropathy.Cystatin C has been suggested one of such markers. The aimof this study was to examine the usefulness of cystatin C as anearly marker of diabetic nephropathy.Methods: It was a retrospective study to evaluate role ofCystatin C in Diabetic nephropathy. 52 patient’s report fromdepartment of medicine in Hindu Rao Hospital, were analysedand compared with age related controls.Results: Association was observed between increased levelsof blood urea, serum creatinine and cystatin C withalbuminuria. The association was statistically significant (pvalue < .05). The significant sensitivity and specificity range forcystatin C was better as compared to blood urea andcreatinine.Conclusion: Cystatin C appears to be a better marker fordetection of diabetic nephropathy in comparison to blood ureaand serum creatinine.
ABSTRACT
Background: Defects in insulin action and hyperglycemiacould lead to changes in plasma lipoproteins in patients withdiabetes.These Patients with type 2 Diabetes often exhibit anatherogenic lipid profile, which greatly increases their risk ofcardiovascular deaths compared with people withoutdiabetes.This dyslipidemia may be a treatable risk factor forsubsequent cardiovascular disease.Methods: The study was done at Hindu Rao Hospital Delhi. Aretrospective analysis of 52 patients with Diabetes was done.Patients who were diagnosed as per WHO guidelines fordiabetes mellitus and on statin therapy for at least 3 monthswere chosen for analysis.Results: Results of this study show that the levels of LDL,HDL, TC and TG were significantly higher in type 2 diabetics.Conclusion: Good glycaemic control is required for preventingother associated co-morbid conditions. Therefore,early diagnosis of dyslipidemia can be used as a preventivemeasure for the development of cardiovascular disease (CVD)in type 2 diabetics.