ABSTRACT
The Rationale: Glanzmann thrombasthenia is a rare platelet disorder affecting 0.0001% of the population. Dentists may often be unaware of this condition, and manipulation of soft tissue can lead to grave consequences, which may even result in fatality. Patient Concerns: In this case report, a 4?year?old patient with Glanzmann thrombasthenia reported to the department with a chief complaint of a discoloured tooth. Clinical Findings: On examination, 51 was nonvital, and pulpectomy was the treatment planned. The non?vital anterior tooth was treated with a pulpectomy procedure. There was uncontrolled bleeding during the procedure. Treatment: A topical solution of BotroClot was used to arrest the bleeding, and obturation was completed following that. The post?operative period was uneventful. Take?away Lessons: Case report explored the use of a topical hemostatic agent to arrest bleeding from the canal. This case report warrants eliciting a thorough medical history before any dental procedure.
ABSTRACT
Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.
ABSTRACT
Siddha Medicine is a traditional system of healing medicine in the southern part of the India and some other nations. This system of Medicine is mainly categorized into two classes, based on the root of admiration of the drugs, which are 32 types of Aga marunthugal (Internal medicine) and 32 types of Pura marunthugal (External medicine) for treating the 4448 diseases describe in the Siddha texts. The 32 types of External therapies are included in many kinds of external application of treatment procedures. Siddha texts mentioned the Pugai is termed as Fumigation is one of the external therapies in this system. This study reveals that the Pugai is the effective external treatment procedure to cure some disease condition based on Siddha theory. Fumigation signifies the artificial impregnation of the atmosphere, with the fumes or smoke of any vegetable or aromatic substances. Pugai is an application of fumes is administered in different parts of the body, apart from inhalation. Most of these therapies are aimed to maintaining the healthy balance of tri humours of Vatham, Pitham, Kabam and Saptha thathukkal which mean seven tissue types of the body. Main purpose of this procedure is to reduce microbes and to control infections. Fumigation can be effective in inactivating microbes on environmental surfaces.
ABSTRACT
High performance liquid chromatographic analysis of the total nuclear DNAs of 6 millets plant species indicates that the 5-methylcytosine content ranges from 3% in barn yard millet to 9·6% in great millet while the fraction of cytosines methylated varies between 14% in little millet to 31 % in pearl millet. Digestion of millet DNAs with MspI/HpaII suggests that CpG methylation is more in great millet DNA while CpC methylation is more in the other 5 millet DNAs. Digestion of millet DNAs with MboI, Sau3AI and DpnI indicates that some of the 5’ GATC3’ sequences are methylated at adenine and/or cytosine residues except in little millet where adenine methylation of the 5’GATC3’ sequences is insignificant and there is a predominance of cytosine methylation in these sequences.