ABSTRACT
Objective@#To investigate the effects of epidural analgesia on puerpera and neonatal.@*Methods@#A total of 150 puerpera were continuously enrolled from May 2017 to May 2018 in Zhoushan Maternal and Child Health Care Hospital, and were divided into analgesia group (102 cases) and non-analgesia group (48 cases) according to their prenatal wishes.The analgesia group was given epidural anesthesia for analgesic delivery, while the control group had no analgesia intervention.Differences in the expression of serum pain and stress hormones were compared between two groups at the time of prenatal, postpartum 1h and 24h.At the same time, differences in neonatal NACS scores were compared between two groups at the time of postpartum 1h, 8h and 24h.@*Results@#No statistically significant differences were found between the two groups in prenatal serum pain and stress hormones, but at the time of postpartum 1h and 24h, serum pain media neuropeptide Y (NPY) (t=5.041, P=0.000; t=4.984, P=0.000), 5-hydroxytryptamine (5-HT) (t=3.083, P=0.002; t=4.203, P=0.000), prostate E2 (PGE2) (t=6.764, P=0.000; t=4.364, P=0.000) and stress hormone angiotensin Ⅱ (AngⅡ) (t=3.670, P=0.000; t=2.911, P=0.004), adrenocorticotropic hormone (ACTH)[(212.54±38.65) ng/mL vs.(231.43±34.82)ng/mL, t=3.510, P=0.001; (163.82±33.21) ng/mL vs.(175.21±32.48) ng/mL, t=2.105, P=0.045)]and cortisol (Cor)[(344.56±57.39) μg/L vs.(381.81±59.23)μg/L, t=3.670, P=0.000; (241.27±43.44) μg/L vs.(262.56±37.97) μg/L, t=2.911, P=0.004)] in the analgesia group were significantly lower than those in the non-analgesia group.There were no statistically significant differences in NACS score, complications and Apgar score between the two groups (all P>0.05).@*Conclusion@#The analgesic effect of full-course epidural delivery in analgesic delivery is remarkable, which can effectively reduce maternal stress reaction, and it is safe and has less adverse effect on neonates.
ABSTRACT
Objective To investigate the effects of epidural analgesia on puerpera and neonatal.Methods A total of 150 puerpera were continuously enrolled from May 2017 to May 2018 in Zhoushan Maternal and Child Health Care Hospital,and were divided into analgesia group (102 cases) and non-analgesia group (48 cases) according to their prenatal wishes.The analgesia group was given epidural anesthesia for analgesic delivery,while the control group had no analgesia intervention.Differences in the expression of serum pain and stress hormones were compared between two groups at the time of prenatal,postpartum 1h and 24h.At the same time,differences in neonatal NACS scores were compared between two groups at the time of postpartum 1h,8h and 24h.Results No statistically significant differ-ences were found between the two groups in prenatal serum pain and stress hormones,but at the time of postpartum 1h and 24h,serum pain media neuropeptide Y ( NPY) ( t = 5. 041, P = 0. 000; t = 4. 984, P = 0. 000 ), 5 -hydroxytryptamine (5-HT) (t=3.083,P=0.002;t=4.203,P=0.000),prostate E2 ( PGE2) ( t=6.764,P=0.000;t=4.364,P=0.000) and stress hormone angiotensin Ⅱ(AngⅡ) (t=3.670,P=0.000;t=2.911,P=0.004),adrenocorticotropic hormone (ACTH)[(212.54 ± 38.65) ng/mL vs.(231.43 ± 34.82)ng/mL,t=3.510, P=0.001; (163.82 ± 33.21) ng/mL vs.(175.21 ± 32.48) ng/mL,t=2.105,P=0.045)] and cortisol (Cor) [(344.56 ± 57.39) μg/L vs.(381.81 ± 59.23)μg/L,t=3.670,P=0.000; (241.27 ± 43.44) μg/L vs.(262.56 ± 37.97) μg/L,t=2.911,P=0.004)] in the analgesia group were significantly lower than those in the non-analge-sia group.There were no statistically significant differences in NACS score,complications and Apgar score between the two groups (all P>0.05).Conclusion The analgesic effect of full-course epidural delivery in analgesic delivery is remarkable,which can effectively reduce maternal stress reaction, and it is safe and has less adverse effect on neonates.
ABSTRACT
Objective To investigate clinical effects and safety differences of conventional and low doses of sufentanil combined with ropivacaine for analgesia on painless childbirth.Methods 130 lying-in women with painless childbirth were chosen and randomly divided into two groups including control group (65 cases) with sufentanil for 7.5μg and observation group (65 cases) with sufentanil for 5.0p g combined with ropivacaine;the block onset time,the arrival time at the maximum block level,modified Brcmage score,the Apgar score in 5min after childbirth,the VAS score before and after analgesia and adverse reaction incidence of both groups were compared.Results The sense and motion block onset time and the arrival time at the maximum block level of control group were separately (4.33 ± 1.91) min,(7.50 ± 1.70) min,(14.26 ± 1.50) min.The sense and motion block onset time and the arrival time at the maximum block level of observation group were separately (3.68 ± 1.54) min,(5.73 ± 1.21) min,(9.71 ± 1.15)min.The block onset time and the arrival time at the maximum block level of observation group were significant shorter than control group (t =2.78,3.07,3.47,all P ＜ 0.05).The modified Bromage score of observation group were significant lower than control group (t =2.92,P ＜ 0.05).There was no significant difference in the Apgar score in 5min after childbirth between the two groups(t =1.29,P ＞0.05).There was no significant difference in VAS score before and after analgesia between the two groups (t =1.15,1.02,0.95,0.63,0.87,all P ＞ 0.05).The adverse reaction incidence of observation group were significant lower than control group (x2 =9.24,8.66,12.07,10.45,all P ＜ 0.05).Conclusion Compared with conventional doses of sufentanil,low doses of sufentanil combined with ropivacaine for analgesia on painless childbirth can efficiently accelerate the block onset process and reduce the risk of adverse reactions.