An association study on Gilles de la Tourette's syndrome and catechol-O-methyl transferase gene polymorphism / 中华行为医学与脑科学杂志

ObjectiveTo investigate the association between catechol-O-methyl transferase (COMT)gene polymorphism and Gilles de la Tourette' s syndrome(GTS).MethodsUsing Amplification Refractory Mutation System(ARMS) PCR genotyping assay method,a polymorphism (val158met) of COMT gene was genotyped in 112 of all GTS patients ( total GTS group) including 54 GTS-alone patients group,48 GTS + ADHD patients group among of them and 71 healthy controls.The correlation between positive association of polymorphism (val158met)of COMT gene in GTS and the age of onset in patients with GTS was also analyzed.ResultsCompared with healthy controls group,genotype of val158met did not differ in total GTS patients group or alone-GTS patients group (χ2 =0.56,P=0.756;χ2 =1.05,P=0.600 respectively).There was also no significant difference (P＞0.05)in allele distribution of val158met in total GTS patients group or alone-GTS patients group compared with controls group respectively (χ2 =0.18,P=0.669;χ2 =0.29,P=0.593 respectively).However,genotype distribution of val158met was significantly different between GTS + ADHD patients group and controls group( χ2 =6.35,P =0.041 ).The frequency of the val allele of this locus was significantly higher in GTS + ADHD patients group than those in controls group ( χ2 =5.49,P =0.019 ).The mean age of onset (6.80 ± 1.54 ) in 36 children within GTS + ADHD patients group with the val/val geantype of COMT gene val158met polymorphism was significantly earlier than the mean age of onset (8.04 ± 1.54)in 12 children in val/val genotype (P =0.016 ).ConclusionPolymorphism (val158met) of COMT gene may be associated with GTS children with comorbid ADHD,which may play an important role to make the age of onset in children with GTS become earlier.

A Study of the Schizotypal Personality Traits in the People at High Risk for Schizophrenia / 中国临床心理学杂志

Objective: To explore the personality traits in the people at high risk for schizophrenia.Methods: 188 individuals at high risk for schizophrenia,and 321 normal controls were assessed by Schizotypal Personality Questionnaire(SPQ).Results: The score of negative schizotypal dimension in SPQ in the individuals at high risk was higher than in the normal controls.Conclusion: The people at high risk for schizophrenia have negative schizotypal personality traits which may represent a genetic endophenotype for schizophrnia.

Design and field calculation of coil array for transcranial magnetic stimulation (TMS) based on genetic algorithm / 生物医学工程学杂志

It is the intent of this paper to locate the activation point in Transcranial Magnetic Stimulation (TMS) efficiently. The schemes of coil array in torus shape is presented to get the electromagnetic field distribution with ideal focusing capability. Then an improved adaptive genetic algorithm (AGA) is applied to the optimization of both value and phase of the current infused in each coil. Based on the calculated results of the optimized current configurations, ideal focusing capability is drawn as contour lines and 3-D mesh charts of magnitude of both magnetic and electric field within the calculation area. It is shown that the coil array has good capability to establish focused shape of electromagnetic distribution. In addition, it is also demonstrated that the coil array has the capability to focus on two or more targets simultaneously.

Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To investigate whether DRD4 exon III48 bp variant number tandem repeat(VNTR) polymorphism is associated with tic disorder.</p><p><b>METHODS</b>One hundred and twenty-two nucleus families were collected using Structured clinical interview for genetic study of Tourette syndrome and related disorders for family-based association analysis of tic disorder and DRD4 exon III 48bp VNTR polymorphism. One hundred and twenty-two trios were divided into two groups: tic disorder group (82 trios of Tourette syndrome or chronic tic disorder, TS&CT) and tic disorder accompanied with attention deficit and hyperactivity disorder (ADHD) group (40 trios of Tourette syndrome or chronic tic disorder accompanied with ADHD, TS&ADHD). Transmission disequilibrium test (TDT), in addition to polymerase chain reaction and VNTR technique were conducted in 122 trios.</p><p><b>RESULTS</b>There exist 5 alleles at this polymorphic locus in this sample including DRD4 exon III 48bp 2-6 repeats. No transmission disequilibrium was found between DRD4 exon III 48 bp VNTR and tic disorder (chi square=7.44, P 0.12); however, when the sample was divided into two groups, transmission disequilibrium was noticed between the cases of TS&ADHD and this locus by overall allele-wise analysis (chi square=11.74, P 0.02), and there exists transmission disequilibrium exclusively between 5 or 6 repeats of 48bp VNTR(longer alleles) by allele-wise analysis (chi square=10.57, P 0.032, chi square=6.13, P 0.01). No transmission disequilibrium was seen between TS&CT and DRD4 exon III 48bp VNTR(chi square=3.38, P 0.50).</p><p><b>CONCLUSION</b>The results of this study have revealed an association between the longer alleles of DRD4 exon III 48bp VNTR polymorphism and tic disorder accompanied with ADHD, thus suggesting a possible genetic risk factor of tic disorder accompanied with ADHD in Chinese.</p>

Suicide Ideas of Middle School Students / 中国心理卫生杂志

Objective:To study the associated factors with suicide ideas in middle school students.Method:Multiple random sample method was used in the study. 1421 middle school students in Chengdu urban area were sampled and 1393 gave effective feedback. Self-made questionnaire (including age, sex, family circumstance, experience in childhood, substance abuse, question about suicide ideas, etc.), Beck Depression Inventory (BDI), Adolescent Self-Rating Life Events Check List (ASLEC) were applied to the students.Results:328 (23.5%) of the 1393 have suicide ideas. The risk factors of suicide ideas included: 1) family factors: parents' divorce, father/mother's passing away, remarried family, experienced abuse in childhood, violence or suicide behavior of family member. 2) school factors: bullying or being bullied. 3) substance abuse: smoking, drinking and addictive drugs abuse. 4) high score of BDI. 5) high score in inter-person relation factor and being punished factor of ASLEC. 6) sex factor: female. Protecting Factors of suicide ideas included better achievement in school, singleton in family and harmony of family member.Conclusion:Suicide ideas were not rare in middle school students. Clinicians and teachers should discover and try to prevent possible suicide as early as possible.

Childhood Experience, Family/School Factors and Depressive Emotion in Middle and High School Students / 中国心理卫生杂志

Objective: To investigate the related factors to depression in middle and high school students Method: The BDI (Beck depression inventory), EMBU (Egna Minnen av Barndoms Uppufostran, own memories of parental rearing practices in childhood) and a self-designed psychosocial factor inventory were administrated to 1382 students in middle or high schools Result:The BDI score was positively correlated to some factors in EMBU, they were firm control and punishment, over-interference, rejection and deny, and over-protection Compared with those with low BDI score, the group with higher BDI score had more experiences of fosterage, being maltreated by family members, reared in inharmonious family, unhappy childhood and with more family history of suicide or violent behavior More of them were still in abnormal families, with poor parent-child relationship Their parents had less expectancy on them, they had poor academic achievement, even failed in go up to next grade; they were more bullied and inclined to bully peers, had no good friend, taking less sports or other entertainment, had less opportunity to be assumed class or school service jobs More of them were just before graduation Conclusion:Poor family background, poor school performance and academic stress are risk factors for depression of middle or high school students

Correlation between YSR and CBCL / 中国心理卫生杂志

Objective:to study the relationship between YSR and CBCL in adolescents.Method:466 adolescents were collected from 3 middle or high schools by striated random sampling. YSR (youth self report) and CBCL (child behavior checklist) were applied to the adolescents,and their parents .Result:there were 103 questions same in both YSR and CBCL, the Kappa=0.001-0.218 (P=0.975～0.000). In male, the result of YSR was correlated with only one syndrome in CBCL, in female, it correlated with 7 syndromes, introversion/extroversion, and the total score of CBCL. In middle school students, the result of YSR correlated with all subscores of CBCL. In adolescents of core family, in good relationship with parents, with father had higher educational level (high school), the result of YSR correlated with most of the subscores of CBCL.Conclusion:in the population of male, high school students, of non-core family, or in poor relationship with parents, results of YSR and CBCL are not consistent.

Reliability and Validity of Chinese Revision of the Anxiety Sensitivity Index-Revised / 中国心理卫生杂志

Objective: To develop the Chinese version of the Anxiety Sensitivity Index-Revised and examine its replicability, reliability and validity. Methods: This study translated the Anxiety Sensitivity Index-Revised ( ASI-R) and examined the factor analytic structure of anxiety sensitivity in a large sample of middle school students aged 12-18 years (n = 1556) . Factor analysis of the ASI-R items resulted in a hierarchical construct with three lower-order factors loading on a single higher-order factor. Results: after revision, the number of items of the inventory reduced from 36 to 15. Anxiety sensitivity seems to be a hierarchically organized construct with one higher-order factor (anxiety sensitivity ) and three lower-order factors: Physical concern, Cognitive concern (lose of control) , Social concern, which three factors contributed to 52. 29% of total variance. Factor loadings of items were 0. 63 ~ 0. 98 , the internal correlation between items were 0. 37 ~ 0. 53 , the correlation between factors to the total score were 0. 72 ~ 0. 84, internal correlation among factors were 0. 68 ~ 0. 78. internal consistency of each factor 0. 73 ~ 0. 78. the split-half reliability was 0. 71 ~0. 76, that of test-retest was 0. 70 ~0. 78. Conclusion: The questionnaire has satisfying reliability and validity.