Application of Mendelian randomization analysis in exploring the etiology of nonalcoholic fatty liver disease / 临床肝胆病杂志

Nonalcoholic fatty liver disease （NAFLD） is an abnormal lipid metabolic disorder of the liver characterized by accumulation of a large amount of lipids in the liver， and it is currently the most common liver disease around the world. Mendelian randomization （MR） incorporates genomic data into traditional epidemiological study designs to infer the causal relationship between exposure factors and disease risk. In recent years， MR has been widely used in studies on inference of the etiology of NAFLD. This article systematically summarizes the advances in the application of MR in NAFLD research， so as to provide new ideas for understanding the nature of the disease and scientific interventions.

The study of HLA-A,DRB1 allele polymorphism in cirrhosis patients due to hepatitis B / 中国免疫学杂志

Objective:In order to find a possible relationship between the polymorphism of HLA A,DRB1 allele and susceptibility to cirrhosis due to hepatitis B.Methods:HLA A,DRB1 allele polymorphism in 61 patients with cirrhosis due to hepatitis B were analyzed by DNA chip,146 healthy subjects as control group were also tested.Results:The most frequent alleles were HLA A02,11,24 for HLA A locus and HLA DRB112,09,04 for HLA DRB1 locus in control group respectively,the significantly increased frequencies of HLA A02(43 4% vs 29 1%,OR:1 87,P=0 005,95% CI:1 21 2 89)与HLA DRB107(13 9% vs 5 1%,OR:3 00,P=0 002,95% CI:1 48 6 07)、HLA DRB108(16 4% vs 6 8%,OR:2 67,P=0 003,95% CI:1 40 5 08)、HLA DRB111(12 3% vs 5 8%,OR:2 27,P=0 025,95% CI:1 11 4 64) were found in cirrhosis patients due to hepatitis B compared to the control group,the homozygotes of HLA A02 showed a tendency to increase in cirrhosis patients,but failed to reach statistical significance.Conclusion:HLA A02 and HLA DRB107、08、11 may be susceptibility genes for cirrhosis due to hepatitis B. [