ABSTRACT
Objective:To observe the combination effect of doxorubicin andCitrus hystrix(kaffir lime’s) peel ethanolic extract(ChEE) on blood serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activity and cardio-hepato-histopathology of femaleSpragueDawley rats. Methods:Doxorubicin andChEE(5 rats per group) were administered in five groups of3 rats each for11 d.GroupI: doxorubicin(dox)4.67 mg/kg body weight;GroupII: dox+ChEE500 mg/kg body weight;GroupIII: dox+ChEE1000 mg/kg body weight;GroupIV:ChEE1000 mg/kg body weight;GroupV: untreated(control).Results:ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity ofALT andAST.Conclusion:ChEE has potency to be developed as cardioprotector agent in chemotherapy.