ABSTRACT
Enchondromatosis or Ollier syndrome is defined by the presence of multiple enchondromas with an asymmetrical distribution of low prevalence. Enchondromas are common intra osseous benign cartilage tumors cartilaginous which develop to close proximity growth plate cartilage. Cartilage injuries can be very variable in terms of size, number, location, evolution of enchondroma, age of onset and of diagnosis, requirement for surgery. Clinical problems caused by enchondromas include skeletal malformations, an asymetrics hortening of extremity with limping, and potential risk of malignant change to chondrosarcoma. The condition in which multiple enchondromatosis is associated to soft tissue hemangiomas is known as Maffucci syndrome. So far, both Ollier disease and Maffucci syndrome have occurred only in isolated cases. It has not been established if the disease depends on a single gene or combination of several mutations. The diagnosis is based on clinical and radiological conventional analysis. Histological analysis has a limited role and is used if malignancy is suspected. There is no medical treatment for enchondromatosis. Surgical treatment is recommended only in case of complications. Though, it is difficult to establish a prognosis for Ollier disease, it is found that the early onset forms are usually more severe.
Subject(s)
Humans , Female , Child , Enchondromatosis/diagnosisABSTRACT
La evolución severa de la infección respiratoria aguda baja (IRAB) por VRS se observa en lactantes con y sin factores clásicos de riesgo. La gravedad puede depender del huésped, virus y/o ambiente. Nuestro objetivo fue evaluar la asociación del grupo A y B a una mayor severidad. Estudiamos lactantes previamente sanos, hospitalizados por IRAB por VRS. Comparamos severidad clínica de grupo A y B. VRS B predominó en 1994, A lo hizo entre 1995 y 1997 y entre 1999 y 2002; en 1998 la proporción de VRS A y B fue similar, apareciendo primero A y luego B. Los grupos no mostraron diferencias significativas en días de hospitalización o ingreso a UTI; el requerimiento de oxígeno fue significativamente mayor en el grupo B, con predominio de neumonías. Concluimos que la severidad de las IRAB por VRS se asocia marginalmente a VRS B, ya que este grupo presentó más neumonías puras y necesidad de oxígenoterapia.
The more severe primary acute lower respiratory tract infection (ALRI) due to RSV is seen in infants with underlying diseases but also in previously healthy infants. Severity depends on host factors, viral strain and/or environment. Our aim was to determine the association of RSV A and B with severity. We studied previously healthy infants hospitalized due to RSV ALRI. We compared the clinical severity of groups A and B. RSV B was predominant in 1994, RSV A in 1995 to 1997 and in 1999 to 2002. In 1998 the proportion of RSV A and B were similar. Both groups did not differ in hospital stay, admission to ICU or mechanical ventilation. Oxygen requirements and a diagnosis of pneumonia were more frequent in RSV group B. We conclude that severity of RSV ALRI is little associated to viral strain, RSV group B presented with more pneumonias and oxygen requirements.