ABSTRACT
In this randomized controlled multicenter trial, we compared endoscopic variceal banding ligation (VBL) with propranolol (PPL) for primary prophylaxis of variceal bleeding. One hundred fifty-two cirrhotic patients with 2 or more esophageal varices (diameter >5 mm) without prior bleeding were randomized to VBL (n=75) or PPL (n=77). The groups were well matched with respect to baseline characteristics (age 56±10 years, alcoholic etiology 51%, Child-Pugh score 7.2±1.8). The mean follow-up was 34±19 months. Data were analyzed on an intention-to-treat basis. Neither bleeding incidence nor mortality differed significantly between the 2 groups. Variceal bleeding occurred in 25% of the VBL group and in 29% of the PPL group. The actuarial risks of bleeding after 2 years were 20% (VBL) and 18% (PPL). Fatal bleeding was observed in 12% (VBL) and 10% (PPL). It was associated with the ligation procedure in 2 patients (2.6%). Overall mortality was 45% (VBL) and 43% (PPL) with the 2-year actuarial risks being 28% (VBL) and 22% (PPL). 25% of patients withdrew from PPL treatment, 16% due to side effects. In conclusion, VBL and PPL were similarly effective for primary prophylaxis of variceal bleeding. VBL should be offered to patients who are not candidates for long-term PPL treatment.
Subject(s)
Humans , Adrenergic beta-Antagonists/therapeutic use , Esophageal and Gastric Varices/drug therapy , Esophageal and Gastric Varices/surgery , Evidence-Based Medicine , Gastrointestinal Hemorrhage/prevention & control , Propranolol/therapeutic use , Esophagus/surgery , Randomized Controlled Trials as Topic/standards , Treatment OutcomeABSTRACT
El síndrome del "hombre en el barril" se refiere al cuadro clínico de paresia braquial proximal bilateral, que es habitualmente secundaria a una hipotensión arterial sistémica con hipoperfusión encefálica, resultando en una isquemia de zonas limítrofes. Reportamos el caso de un hombre de 57 años, con paresia braquial proximal bilateral después de una cirugía biliar debido a una colangitis. La difusión en resonancia magnética mostró lesiones hiperintensas en la zona correspondiente al límite entre los territorios de las arterias cerebrales media y anterior derechas.