ABSTRACT
El objetivo del estudio fue estimar la prevalencia de los distintos alelos del polimorfismo del gen de la enzima convertidora de angiotensina (ECA), inserción/deleción (I/D) y simultáneamente la actividad de ECA plasmática (pl) asociada en población sana chilena normotensa. 117 sujetos sanos normotensos (entre 45 y 60 años, de nivel socioeconómico medio, no obesos ni diabéticos) fueron seleccionados de un estudio poblacional sobre prevalencia de factores de riesgo de enfermedades crónicas. Las frecuencias de los alelos I y D fueron 0,57 y 0,43 respectivamente. La actividad de ECApl fue en promedio 15,3ñ3,9 U/mL. Comparado con sujetos con genotipo II, la actividad de ECApl fue significativamente mayor en sujetos con genotipo ID y DD sin diferencias entre ellos. No se observó correlación entre actividad de ECApl y masa VI en ningún sexo ni en los distintos genotipos. El análisis de regresión lineal multivariado (que usó masa VI e índice de masa VI como variables dependientes mostró efectos independientes (p<0,05) del sexo (mayor masa VI en varones) y de la presión diastólica, pero no del genotipo DD. En conclusión, en esta población la presencia del alelo D del gen de la ECA determina mayor actividad de ECA circulante, lo cual podría estar asociado a mayor morbilidad cardiovascular. En esta población sana normotensa, el sexo masculino y la presión diastólica, pero no la presencia del alelo D, están asociados a mayor masa VI
Subject(s)
Humans , Male , Female , Middle Aged , Peptidyl-Dipeptidase A/genetics , Polymorphism, Genetic , Chromosome Deletion , Peptidyl-Dipeptidase A/blood , Blood Pressure/geneticsABSTRACT
Background: In the last decades, chronic non communicable diseases are becoming the main cause of disability and mortality among adults. The risk factor surveillance and management is the most efficient mean of reducing the impact of these diseases. Aim: To report the results of a non communicable disease risk factor surveillance program in Valparaiso, Chile. Material and methods: a random samples of people aged 25 to 64 years old living in Valparaiso, Chile was studied. Subjects were questioned about smoking and physical activity habits. Blood pressure, height and weight were measured using standardized techniques at their homes and blood samples were obtained to measure serum lipid levels and oral glucose tolerance test at the nearest outpatient clinic. Results: Of the initial 3852 homes selected, 752 individuals did no agree to answer the inquiry, therefore 3120 subjects were finally interviewed. Of these, 40.6 percent were smokers, 15 percent drank alcohol in two or more occasions per month, 84.6 percent were physically inactive, 19.7 percent had a body mass index over 30 kg/m2, 11.1 percent had high blood pressure, 3.9 percent were diabetic and 46.9 percent had high serum cholesterol levels. Conclusions: The basal survey for the CARMEN program shows a high prevalence of cardiovascular risk factors among chileans
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Diabetes Mellitus/epidemiology , Hypercholesterolemia/epidemiology , Hypertension/epidemiology , Smoking/epidemiology , Chile/epidemiology , Simple Random Sampling , Risk Factors , Alcoholism/epidemiology , Educational Status , Obesity/epidemiology , Age Distribution , Sex Distribution , Socioeconomic Factors , Health Promotion , Epidemiological MonitoringABSTRACT
Background: There is little information about the real prevalence of hypertension in Chile. Aim: To assess the adjusted prevalence of hypertension and its main therapeutic measures among adults living in Valparaiso, Chile. Material and methods: A random sample of dwellings in Valparaiso was chosen. Among these, an individual of 25 to 64 years old was randomly surveyed for risk factors for chronic diseases and sociodemographic parameters. Blood pressure, weight, height, oral glucose tolerance test, fasting cholesterol and triglycerides were also measured. Prevalence was pondered according to age, sex, and probability of selection in the dwelling interior. Results: Three thousand one hundred twelve individuals were studied. The adjusted prevalence of hypertension was 11.4 percent (11.6 percent among females and 10.6 percent among men). The prevalence increased along with age from 3 and 1.9 percent in men and women of 25 to 34 years old respectively, to 18.2 and 27.4 percent among men and women of 55 to 64 years old (p< 0.01). People of low socioeconomic level had a higher prevalence of hypertension than those of high socioeconomic level (14.2 and 9.3 percent respectively, p < 0.05). Diabetes, obesity and hypercholesterolemia were significantly more frequent in subjects with hypertension than in the general population. Forty four percent of diagnosed hypertensives were receiving medications (angiotensin converting enzyme inhibitors 40 percent, calcium antagonists 34 percent, beta blockers 22 percent). Twenty five percent of patients were treated with a combination of medications. Of those treated, only 22 percent had normal blood pressure levels at the moment of examination. Conclusions: High blood pressure is an important public health problem that requires more efficient detection and treatment programs