ABSTRACT
Background: Oral squamous cell carcinoma (OSCC) is a commonly occurring head and neck cancer. It has a high prevalence, and is associated with a high mortality rate. OSCC occurs due to many etiological factors, but smoking and alcohol remain the most common risk factors. The histological grading of tumors has been used to predict the clinical behaviour of OSCC. Broder’s initiated quantitative grading in cancer. Anneroth’s and Hansen developed another grading system for grading of OSCC’s. With this background, a study was undertaken to compare between Anneroth’s & Broder’s grading systems in oral squamous cell carcinoma in relation to histopathological prognostic factors. Material & Methods: A retrospective study was carried out on 50 formalin fixed paraffin embedded tissue blocks of the confirmed cases of Oral squamous cell carcinoma in the archives of department of oral pathology, Govt. Dental College & Hospital, Srinagar. The cases were evaluated on the basis of Broder’s & Anneroth’s grading systems for OSCC & the comparison of the systems was made pertaining to histopathological prognostic parameters. Results: In our study according to Anneroth’s system maximum cases comes under grade III while in Broder’s system maximum cases are in grade I & II. Conclusion: Anneroth’s classification provides us a detailed analysis of grading the cases according to scoring of each parameter. Thus, it is more informative than Broder’s grading system.
ABSTRACT
Background: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy, representing up to 80–90% of all malignant neoplasms of the oral cavity. The increasing cases of oral cancer are the most important concern for community health. Defects of mitosis result in various nuclear abnormalities namely micronuclei, binucleation, broken egg appearance, pyknotic nuclei, and increased numbers of mitotic figures. The rationale for mitotic counting is that it is frequently used for classification and grading of tumors, prediction of prognosis of tumors and even advocated as a decision point for treatment. Reproducibility of the mitotic counting is paramount for the assessment of malignancy on a histologic scale. Considering this, we decided to assess the inter-observer variability in mitotic figure counting in various grades of oral squamous cell carcinoma. Material & Methods: A retrospective study was carried out on 48 formalin fixed paraffin embedded tissue blocks of the confirmed cases of Oral squamous cell carcinoma in the archives of department of oral pathology, Govt. Dental College & Hospital, Srinagar. Mitotic figure counting was done by two independent, mutually blind observers. The data was assessed for inter-observer variability in counting of figures. Results: Least difference was seen in cases of WDSCC up to the maximum difference of 3 mitoses. MDSCC showed modest differences in observations, with a maximum difference of 4 mitoses. PDSCC cases had the highest inter-observer variability, with a maximum difference of 5 mitoses. Conclusion: Mitosis counting has been shown most convincingly to provide independent prognostic value and is the most well established component of the histological grading systems of OSCC. Reproducibility of the mitotic counting is paramount for the assessment of malignancy on a histologic scale.
ABSTRACT
Background: Personal identification is a subtle perception and often one of the most significant priorities in the investigation of criminal cases, mass disasters, and in forensic concerns. Gender determination is one of the important parameters in forensic identification. The study of anthropometric characteristics is of fundamental importance to solve problems related to such cases. Aim: This study aimed to determine gender using physical anthropometric methods like interzygomatic and intercanthal width. Materials and Methods: A cross-sectional study was conducted among 60 individuals (30 males and 30 females) in the department of Oral Pathology, Government Dental College and Hospital Srinagar. Interzygomatic width, and intercanthal width was determined using a digital sliding caliper. All the measurements were taken twice. The final value was the average of the two obtained values. Results: There was significantly higher mean interzygomatic and intercanthal width in males as compared to females. Conclusion: Interzygomatic and intercanthal measurements may serve as diagnostic markers for gender identification in forensic applications like mass disasters.
ABSTRACT
Oral pathology, a unique and diversified branch of dentistry that identifies and manages oral diseases pertaining to the oral and maxillofacial region. Aim and objectives: To evaluate and assess the dental students oriented towards oral pathology and also to take necessary measures for further improvement of the teaching process. Methods: A descriptive cross sectional study was carried out in the department of Oral Pathology, GDC Srinagar where the prepared questionnaires was given to all the undergraduate students and interns of GDC, Srinagar except first year BDs and postgraduate students. The questionnaire was in the form of multiple choice questions and designed in such a way which was simple to evaluate and answer. Results: In this study, dental students should have adequate knowledge of this subject but there are still holes between the understanding and awareness for this subject in the students. Conclusion: This study emphasized the difficulties felt by the dental students in their recent curriculum in the subject of oral pathology. By making little alterations in the current schedule, it can be made more interesting and systematic for the students.
ABSTRACT
Dental anatomy and oral histology as a subject need comprehensive information for its application in every wake of academic as well as clinical life. It’s also the responsibility of the trainers for a brighter prospect and enhancement in their academic field. Aim and objectives of the study: To analyze the problems encountered by the dental students in understanding oral histology and dental anatomy as well as to find out the necessary solutions to overcome these problems. Methods: A descriptive cross sectional study will be conducted in the department of Oral Pathology, GDC Srinagar where the prepared questionnaires will be distributed to all the undergraduate students and interns of GDC, Srinagar. The questionnaire will be in the form of multiple choice questions and designed in such a way which will be simple to understand and answer. Results: In the present study, dental students have satisfactory knowledge of this concerned discipline of dentistry but there are still gaps between the understanding and interest for this subject in the students. Conclusion: In the present study, students felt problems/difficulties which are easy to handle if proper measures are taken. By making few variations in their recent curriculum, it can be make more interesting and comprehensive for the future aspirants
ABSTRACT
Background: Various grading systems have been suggested in the literature by different authors to determine the severity of dysplastic features. Histopathological grading is subjective with low reproductivity and lacks sensitivity. Aim: To determine the inter observer and intra observer variability in diagnosing oral epithelial dysplasia using different grading systems. Materials and methods: Three oral pathologists from the Department the Oral pathology, GDC Srinagar observed the same 30 consecutive sections of oral epithelial dysplasia. Each reviewing pathologist asked to grade each case on the basis of WHO (2005) and binary grading system (2006) at different time intervals and was repeated twice. Results: The inter observer variability ranged from poor to slight in WHO system and slight to fair in binary system whereas the intra observer variability ranged from slight to fair in WHO system and fair in the binary system. Conclusion: Grading of oral epithelial dysplasia is subjective and has been shown not to be highly reproducible. The binary grading system verified to have better inter observer and intra observer agreement in the present study than the WHO grading system.