ABSTRACT
Context: beyond the objective outcomes of metabolic syndrome [MetS], the association between this syndrome and its patient centered outcomes need to be investigated in Middle-Eastern countries. This report aims to summarize the Tehran lipid and glucose study [TLGS] findings regarding the association between MetS and health-related quality of life [HRQoL] and its influential factors through the past decade
Evidence Acquisition: the current review has been conducted on the TLGS published data regarding different aspects of the association between MetS and HRQoL in adult participants through the last decade. To assess HRQoL, the Iranian version of short form health survey [SF-36] was used. To define MetS the most commonly used insulin resistance [IR]-and waist circumference [WC] - based MetS definitions have been applied in the publications reviewed
Results: as a whole, MetS was a determinant of poor physical HRQoL only in women [OR: 1.78; 95% CI: 1.21 - 2.61], particularly in those with more component of MetS [P < 0.001]. Results further showed that only reproductive aged women with MetS were more likely to report poor PCS compared to those without MetS even after adjusting for age [OR: 1.7, 95% CI: 1.0 - 3.0; P < 0.05]. Different structures of MetS and physical HRQoL constructs in men and women as well as age and smoking with significant gender-specific effects on mental HRQoL were factors responsible for the gender specific pattern observed. Considering the duration of MetS, only women with intermittent MetS indicated higher risk for reporting poor PCS [OR: 2.75, 95% CI: 1.19 - 6.37; P < 0.001] compared to those without MetS. The observed sex-specific pattern used to detect poor HRQoL in those with MetS was confirmed by all WC-based definitions except for the American Heart Association/National Heart, Lung, and Blood Institute [AHA/NHLBI] definition. However, none of IR-based definitions could detect poor physical and mental HRQoL in either gender
Conclusions: in summary, in the TLGS population, the association between MetS and HRQoL followed a sex specific pattern, mainly significant only in women and in the physical aspect
ABSTRACT
Identifying the risk factors of recurrence of a disease is important both for physicians and patients. Analyzing the first recurrence may lead to an inaccurate evaluation of risk factors as it may not reflect the history of disease completely and may result in the loss of some valuable information. This study was aimed to analyze the time up to the recurrent relapses of schizophrenia as well as determining the risk factors that lead to the recurrence of the disease. In this study 159 registered schizophrenia patients at Razi hospital were selected from a longitudinal study. The effect of age, sex, marriage, start of disease, and history of head trauma variables on recurrence of disease was assessed by a frailty model. Data analysis was made on by R 2.14.1. Mean of patients' age was 21.5 +/- 6.6 year. Based on the Gamma frailty model, sex of patients [p=0.045] and history of head trauma [p=0.028] had significant effect on the hazard of recurrent relapses of Schizophrenia. In addition, the correlation of first, second and third times of recurrence was significant [p<0.001]. Based on the dependency between relapses, treatment and follow-up actions are suggested within the first recurrence time