ABSTRACT
The entry of Toxoplasma gondii into the bloodstream and other tissues [such as liver, muscle, cardiac muscle, ...] of intermediate hosts and its multiplication in nucleated cells may cause changes in plasma levels of various enzymes due to tissue damage. In present study the serum levels of AST, ALT, ALK/P, CPK, LDH, and ACP in rats infected experimentally with Toxoplasma gondii have been investigated. Totally, 116 uninfected rats were divided into 87 as case group and 29 as control group. The case group was infected intraperitoneally with 50000 tachyzoites. Blood specimens were taken from cases and its control once every 8 hours in the first three days and then once every three days for a period of 60 days and serum levels were measured for the mentioned enzymes. During the study, the following changes were observed: AST in the first 8 hours, from the 32[th] hour till the 40[th] hour and from the 48[th] hour till the 56[th] hour; ALT in the first 8 hours and from the 48th hour till the 56[th] hour; ALK/P from the 24[th] hour till the 40[th] hour and from the 48[th] hour till the 64[th] hour; CPK and LDH from the 24[th] hour till the 40[th] hour and from the 48[th] hour till 56[th] hour; ACP from the 16[th] hour till the 48[th] hour. But afterward, whole offer mentioned enzyme shifted to normal levels. Alteration in serum enzyme levels of rats during infection with Toxoplasma gondii found is not permanent