ABSTRACT
@#Objectives: The aim of this study is to evaluate the remedial effect of continuous positive airway pressure (CPAP) therapy on neurocognitive function in obstructive sleep apnoea (OSA) patients. Methods: The cognitive impairment in OSA patients was evaluated with Montreal Cognitive Assessments (MoCA) before and after CPAP therapy. The study assessed 54 patients who were diagnosed with OSAS seen at the neurology clinic of the Trakya University Medical Faculty. They were given MoCA the day of diagnosis, after one day of CPAP therapy, and after three months of CPAP therapy. Results: MoCA scores before treatment showed a statistically significant correlation between disease severity and abstract thinking (Correlation coefficient: 0.270±0.048). There was no significant difference between MoCA scores before treatment and after one day of CPAP therapy (p=0.244). However, there were significant improvements in MoCA scores after three months of treatment, when compared to scores from before treatment and after one day of therapy (p<0.001). Conclusions: CPAP treatment may improve cognitive function in OSA patients. MoCA is an effective and simple tool for evaluating cognitive function.
ABSTRACT
Background and Objective: Acute ischemia reperfusion [IR] injury observed in the lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Preoperative pregabalin has been used as a part of multimodal analgesia in postoperative pain treatment in recent years. Pregabalin has become one of the increasingly common agents in postoperative analgesia. In this study, we aimed to investigate the effect of pregabalin on erythrocyte deformability in rats undergoing IR
Methodology: 24 male Wistar albino rats weighing between 200-250 g were used in the study. Rats were randomly divided into 4 groups of 6 rats each [Control, Ischemia- Reperfusion [IR], IR-Pregabalin 50 mg [50 mg/kg], IR-Pregabalin 200 mg [200 mg/ kg]. Pregabalin was administered intraperitoneally 30 min before the procedure. An atraumatic microvascular clamp was placed across the infrarenal abdominal aorta in the IR groups. Following 120 min of ischemia, the clamp was removed and reperfusion was continued for 120 min. All rats were euthanized by intraperitoneal administration of ketamine [100 mg/kg] and taking blood from the abdominal aorta. Erythrocytes were seperated from heparinized whole blood samples. Deformability measurements were made in erythrocyte suspensions in phosphate buffered saline. A constant flow filtrometer system was used to measure erythrocyte deformability and relative resistance was calculated
Results: It was found that the formation of ischemia reperfusion increases the relative resistance according to the control group [p < 0.0001]. It was determined that application of pregabalin 50 or 200 mg did not change erythrocyte deformability in ischemia reperfusion-induced rats [p = 0.632, p = 0.811]
Conclusion: The administration of 50 or 200 mg of pregabalin has no negative effect on the erythrocyte deformability in ischemia reperfusion-induced rats. We think that pregabalin can be safely used for analgesia in the cases of IR. However, these findings should be supported by clinical and experimental studies carried out in more detailed and broader series
ABSTRACT
Background: Reperfusion following ischemia can lead to more injuries than ischemia itself especially in diabetic patients. The aim of this study was to evaluate the effect of dexmedetomidine on ischemia-reperfusion injury [IRI] in rats with have hepatic IRI and diabetes mellitus
Methodology: Twenty-eight Wistar Albino rats were randomised into four groups as control [C], diabetic [DC], diabetic with hepatic ischemia-reperfusion injury [DIR], and diabetic but administered dexmedetomidine followed by hepatic IRI [DIRD] groups. Hepatic tissue samples were evaluated histopathologically by semiquantitative methods. Malondialdehyde [MDA], superoxide dismutase [SOD], glutathion s-transpherase [GST], and catalase [CAT] enzyme levels were investigated in liver and kidney tissues as oxidative state parameters
Results: In Group DIR; hepatocyte degeneration, sinusoidal dilatation, pycnotic nucleus, and necrotic cells were found to be more in rat hepatic tissue; while mononuclear cell infiltration was higher in the parenchyme. MDA levels were significantly lower; but SOD levels were significantly higher in Group DIRD with regard to Group DIR. In the IRI induced diabetic rats' hepatic and nephrotic tissues MDA levels, showing oxidative injury, were found to be lower. SOD levels, showing early antioxidant activity, were higher
Conclusion: The enzymatic findings of our study together with the hepatic histopathology indicate that dexmedetomidine has a potential role to decrease IRI?
ABSTRACT
Morgagni hernia is a congenital defect that occurs in adult patients without the presence of a traumatic event. In this case a 76 years old male patient is described who admitted to emergency room with abdominal pain and obstipation. The diaghragma defect was repaired and the herniated sac was reducted in the emergent laparotomy applied