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Objective:To explore the moderating effect of emotional regulation strategies between maladaptive perfectionism and suicidal risk in college students.Methods:Totally 1084 college students[mean age(19 ± 1)years old] in Guangdong were surveyed with the maladaptive subscale of the Chinese version of Frost Multidimensional Perfectionism Scale(CFMPS,including concern over mistakes,parental criticism and doubts about actions),Emotion regulation Scale(ERS,including cognitive reappraisal and expressive suppression),and the Suicide Behaviors Questionnaire-Revised(SBQ-R).Results:The SBQ-R scores were positively correlated with the scores of expressive suppression,maladaptive perfectionism,concern over mistakes,parental criticism and doubts about actions(r =0.14 -0.28,Ps ＜0.01).SBQ-R scores were negatively correlated with the scores of cognitive reappraisal(r =-0.19,P ＜0.01).Maladaptive perfectionism positively predicated suicidal risk(β =0.39,P ＜ 0.001),cognitive reappraisal and the interaction between cognitive reappraisal and maladaptive perfectionism negatively predicated suicidal risk(β =-0.17,-0.14,Ps ＜0.001).Conclusion:It suggests that college students who have higher level of maladaptive perfectionism tend to have higher suicidal risk,and cognitive reappraisal may moderate the relationship between maladaptive perfectionism and suicidal risk.
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To explore the effects of cytotoxin-associated gene A [CagA] positive Helicobacter pylori [H. pylori or HP] infection on circulating B cells producing specific platelet glycoprotein antibodies and the association between therapeutic outcomes in primary idiopathic thrombocytopenic purpura [ITP] patients. A total of 76 newly diagnosed primary ITP patients were included in the study which was conducted at the first affiliated hospital of Shantou University Medical college, in Shantou city China, between January 2013 and January 2014. These patients were tested for H. pylori infection by 13C urea breath test and for anti-CagA antibody in H. pylori positive cases by enzyme-linked immunosorbent assay [ELISA] method. Anti-GPIb and anti-GPIIb/IIIa antibody-producing B cells were measured using an enzyme-linked immunospot [ELISPOT] assay in all ITP patients and 30 controls. Anti-nuclear antibody [ANA] was also detected in ITP patients. The numbers of anti-GPIIb/IIIa antibody-producing B cells in HP+CagA+ patients were higher than in HP+CagA- or HP- patients. However, anti-GPIb antibody-producing B cells were found higher in HP- patients. Analysis of treatment outcomes showed that a therapeutic response was more likely in patients presenting anti-GPIIb/IIIa B cells, but the poor response was found to be associated with anti-GPIb B cells and ANA presences. CagA antigen of H. pylori may induce anti-GPIIb/IIIa antibodies production by a molecular mimicry mechanism. Anti-GPIIb/IIIa and anti-GPIb antibody producing B Cells detection is useful for predicting treatment effects of primary ITP
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<p><b>OBJECTIVE</b>To observe the changes of telomere length and telomerase activity in patients with aplastic anemia (AA), and relationship with immunosuppressive therapy (IST) efficacy, to explore the pathogenesis of AA and the role of telomere length in evaluating immunosuppressive therapy efficacy.</p><p><b>METHODS</b>71 cases of AA patients between September 2010 and March 2013 were enrolled into this study. 3 ml peripheral blood specimens from this cohort of patients were collected to test the telomere length in peripheral blood mononuclear cell (PBMNC) with flow-FISH and detect telomerase activity with TRAP-PCR-ELISA method.</p><p><b>RESULTS</b>Telomere length and age showed negative correlation (b=-0.387, P=0.001) in normal control, NSAA and SAA + VSAA groups, telomere length became shorter with the growth of age, and normal control group telomere length decreased along with the age growth slightly greater than the other two groups (NSAA, SAA+VSAA). Besides the effect of age on telomere length, no significant difference was observed between NSAA and SAA+VSAA groups (P=0.573), and NSAA, SAA+VSAA (30.957 ± 4.502,29.510 ± 5.911)groups were significantly shorter than normal control group (51.086±10.844) (P<0.01). Telomere length in NR group (25.357±4.848)was significantly lower than normal control group (51.086 ± 10.844) (P=0.005), telomere length in CR(32.808 ± 4.685)/PR groups (30.334±4.464) compared with normal control group had no significant difference (P=0.517, P=0.254). Telomere length below 29.21% obviously decreased outcomes of IST. Telomerase activity had significant difference (χ²=20.385, P<0.01). The telomerase activity had no significant difference in terms of age and gender in three groups, multiple comparison found that telomerase activities in SAA + VSAA (0.324±0.178) (P<0.01), and NSAA (0.234±0.175) groups (P=0.002) were significantly higher than normal control group (0.107±0.083).</p><p><b>CONCLUSION</b>Telomere length of PBMNC in AA patients was significantly shortened than normal control group with telomerase activity increased, and telomere shorted more apparently in NR group, these patients should adjust the treatment as early as possible. Telomeres could predict the curative effect of IST.</p>
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Young Adult , Anemia, Aplastic , Therapeutics , Case-Control Studies , Immunosuppression Therapy , Leukocytes, Mononuclear , Metabolism , Telomerase , Metabolism , Telomere , Metabolism , Treatment OutcomeABSTRACT
Multiple myeloma (MM) is a clonal B-cell disorder in which malignant plasma cells (PC) accumulate in the bone marrow and produce lytic bone lesions and excessive amounts of monoclonal immunoglobulin. The diagnosis of MM requires the examination of bone marrow, showing PC infiltration, detection and quantification of monoclonal immunoglobulin in the serum or urine and evidence of organ damage (hypercalcemia, renal insufficiency, anaemia or bone lesions). This review discusses the significance of immunotyping for diagnosis and prognosis of MM.