ABSTRACT
Objective To evaluate the predictive value of pre-eclampsia with the combination of inhibin A,activin A and uterine artery doppler.Methods The single pregnant pregnant women were divided into 9-12 week of pregnancy groups and 13-16 week of gestation group based on examination of gestational age.According to the outcome of further follow-up the women are divided into normal pregnancy (9-12 week pregnant or 13-16 week pregnant normal group) and the PE group (9-12 weeks pregnant or pregnant 13-16 PE group).Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of inhibin A and activin A.Doppler ultrasound were used to examine UAPI.The results were converted to MoM values to calculate the combined detection specificity and sensitivity.Results The concentration of serum inhibin A and activin A and UAPI in 9-12 week pregnant PE group were significantly higher than that in 9-12 week normal pregnant (P ＜0.05).The concentration of serum inhibin A and activin A and UAPI in 13-16 week pregnant PE group were significantly higher than that in 13-16 week normal pregnant (P ＜0.05).When the maximum area under the curve of three indicator combined application (AUC =0.836) in 9-12 week pregnant,the specificity was 72％ and the sensitivity was 83％.When the maximum area under the curve of three indicators combined application (AUC =0.912) in 13-16 week pregnant,the specificity was 87％ and the sensitivity was 86％.Conclusion The combined application of peripheral blood inhibin A,activin A and UAPI could predict PE.The combined application of three indicator detection index provides a high degree of specificity,sensitivity and predictive value in 13-16 week pregnant.