ABSTRACT
@#Objective To explore the effects of community-based comprehensive intervention on social function and quality of life of patients with bipolar disorder. Methods 244 bipolar disorder patients were assigned into control group (n=119) and intervention group (n=125). The control group accepted antipsychotics only, and the intervention group accepted community-based comprehensive intervention in addition. They were assessed with Social Disability Screening Schedule (SDSS) and Generic Quality of Life Inventory-74 (GQOLI-74) before and 6, 12 months after treatment. Results The SDSS score was lower (P<0.05) and the GQOLI-74 score was higher (P<0.05) in the intervention group than in the control group. Conclusion Community-based comprehensive intervention can improve the social function and quality of life of patients with bipolar disorder.
ABSTRACT
Objective To study the effects of enriched environment on the capacity of learning and memory and expression of brain derived neurotrophie factor(BDNF) expression of CA1 hippocampus in Wistar rats. Methods 20 male Wistar rats were raised from weaning(21 days old) to young adulthoed(50 -60 days old) in either an enriched or normal environment. The ability of learning and memory was measured with the Morris water maze test,and the expression of BDNF of CA1 hippocampus neuron was detected by immunohistochemistry. Results During Morris water maze test, the mean latency in enriched environment group was significantly shorter than that in the normal control group(24.37±5.45)s Vs (31.28±5.39)s;the time taken to cross the target in enriched environment group was significantly more than that in the normal control group(3.38±0.79)Vs (2.21± 0.49);the swimming distance of platform quadrant increased in the enriched environment group, and the decreased gray intensity of BDNF expression in CA1 hippoeampus was found in the enriched environment group. Conclusions Enriched environment can improve the capacity of learning and memory of the rats, which were realized may be through BDNF pathway.