Preparation of medical chitosan microspheres improved with polyvinyl alcohol and its adsorption test of blood lipids / 中国海洋药物

Objective To prepare medical chitosan microspheres used in blood lipid adsorption. Methods Medical chitosan microspheres were prepared by suspending chitosan in liquid paraffin, adding proportional glutaraldehyde as crosslinking agent and a small amount of polyvinyl alcohol(PVA) to improve its flexibility. The blood lipid adsorption v/ere studied in a dynamic way. Results The medical chitosan microspheres containing a small amount of PVA were more effective in decreasing the contents of cholesterol(CH) , triglyceride(TG) , LDL in human serum. Conclusion The chitosan microspheres obtained by adding a small amount of PVA could be used as a desirable medical microsphere in the adsorption of blood lipids.