ABSTRACT
Objective:To evaluate the efficacy of Peiyuan Kangai Decoction combined with acupuncture in the treatment of advanced liver cancer with qi deficiency and blood stasis syndrome.Methods:Randomized controlled trial. From May 2019 to May 2021, 162 advanced liver cancer patients with qi deficiency and blood stasis syndrome in Shizhong District Cancer Hospital of Leshan were randomly divided into three groups by random drawing method, with 54 in each group. All patients were given FOLFOX4 chemotherapy regimen. Based on the chemotherapy, the 1st control group was given Peiyuan Kangai Decoction, and the 2nd control group was given acupuncture therapy, and the combined group was given decoction and acupuncture therapy. All three groups were treated for 6 weeks. Traditional Chinese Medicine syndrome score was performed before and after treatment, Piper fatigue scale was used to evaluate the fatigue degree of patients. Vimentin (VIM), Golgi transmembrane glycoprotein 73 (GP73) and chemokine ligand 1 (CXCL1) were determined by ELISA. The adverse reactions during treatment were observed and the clinical efficacy was evaluated.Results:The combined group showed the response rate was 61.11% (33/54), the disease control rate was 72.22% (39/54), the 1st control group showed the response rate was 40.74% (22/54), the disease control rate was 53.70% (29/54), and the 2nd control group showed the response rate was 38.89% (21/54), and the disease control rate was 51.85% (28/54). The response rate and disease control rate of the combined group were significantly higher than either the control group 1 and 2 ( χ2 values were 6.59, 5.68, respectively, and P values were 0.037, 0.043, respectively). After treatment, the scores of liver swelling and pain, fatigue and shortness of breath, anorexia, sallow and emaciation in the combined group were significantly lower than those in the control group 1 and the control group 2 ( F values were 13.90, 15.69, 13.20, 10.55, respectively, P<0.01); the scores of emotions, feeling, behavior and cognition were significantly lower than those in the control group 1 and control group 2 ( F values were 49.55, 27.42, 19.69, 20.55, respectively, P<0.01). After treatment, the levels of serum VIM [(52.54±6.69) ng/L vs. (61.29±7.89) ng/L, (65.11±7.92) ng/L, F=39.63], GP73 [(19.72±3.90) ng/L vs. (24.42±4.23) ng/L, (25.12±4.76) ng/L, F=25.05], CXCL1 [(3.12±0.72) ng/L vs. (4.85±0.95) ng/L, (4.98±0.91) ng/L, F=77.67] in the combined group were significantly lower than those in the control group 1 and the control group 2 ( P<0.01). During the treatment, the incidence of toxic and side effects in the combined group was 18.52% (10/54), the control group 1 was 27.78% (15/54), and the control group 2 was 24.07% (13/54). There was no statistically significant difference in the incidence of toxic and side effects among the three groups ( χ2=1.31, P=0.520). Conclusion:On the basis of FOLFOX4 chemotherapy, combined therapy with Peiyuan Kangai Decoction and acupuncture treatment can improve the symptoms and fatigue of patients with advanced liver cancer, reduce the levels of serum VIM, GP-73, CXCL1, improve the efficacy safely.
ABSTRACT
It is believed that acupuncture science of Buddhist medicine has a long history and great characteristics after the investigation, research and analysis on the historic literature of acupuncture in Chinese Buddhist Canon. The writers tried to give the statements from 4 aspects. 1. Science of acupuncture in the time of Buddha. Firstly, the Buddhist acupuncture was mentioned in the time of Buddha, including substantial acupuncture, finger acupuncture and mental acupuncture. The substantial acupuncture refers to metal needle, plant needle, stone needle, bone needle, etc. Finger acupuncture means taking finger as a needle. Mental acupuncture implies that the Buddhism idea is considered in acupuncture. Secondly, the Buddhist medicine is the combination of acupuncture and herbal medicine. The needle box had become the necessity of the medical scholars in traveling. 2. Achievements of medical Buddhists in dynasties. In the paper, 33 medical Buddhists were listed, such as, etc. They made the great contributions to the development of Buddhist medicine of acupuncture. 3. The characteristics of Buddhist acupuncture in clinical diagnosis and treatment. 1) The combination of acupuncture and herbal medicine and this mutual supplementation; 2) Mutual treatment of acupuncture and psychological therapy; 3) Remarkable therapeutic effects of specific acupuncture techniques, such asneedling technique and acupotomy; 4) Medical cases of Buddhist acupuncture; and 5) Precaution of misdiagnosis and prevention of mistreatment. 4. The penetrating statement of acupuncture techniques by the Buddhists in dynasties. 1) The cause-effect theory is introduced in treatment and diagnosis by medical Buddhists. The effectiveness is achieved through causality system. 2) Cataract is treated with gold needle. 3) The medical master is not qualified if nothing to know on acupuncture. The authors believe that the substantial acupuncture techniques need to be further studied and the non-substantial one requests us to be perceived.
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Moxibustion is one of the important contents of Buddhist medicine. Buddhist medicine considers that besides mugwort leaves, corresponding moxibustion materials can be used in accordance with patient’s condition. Using papaya moxibustion for cramp is a good example. In addition, Buddhist medicine proposes meditative moxibustion, that is, using the fire of visualization and the flame of ideas to treat diseases. This article has a discussion from four aspects: combination of acupuncture and moxibustion to complement each other, treatment of diseases by moxibustion plus other methods, use of meditative moxibustion as a way to treat diseases and unique monk-derived moxibustion.
ABSTRACT
Chinese yew is a medicinal plant which has the largest planted area, better economic effects and ecological benefits in our country. People have insufficient appreciation of centuries-old historical document and abundant cultural connotation of Chinese yew, because Chinese yew had no name in ancient times and some expressions of western countries are still cited at present. Therefore, this paper did a great deal of analysis and reference works focusing on synonym and byname of ancient Chinese yew. Excavation and classification of historical documents of Chinese yew from ancient classics and bibliography had been done by studying 3 503 books, about billions of words been recorded in the Si Ku Quan Shu. These researches made up for simple and inadequate contents of many large tool books, like Chinese materia medica and traditional Chinese medicine, and so on. At the same time, in order to change the situation of no name, uncertain channel tropism, irregular functions of Chinese yew, its property and flavor, channel tropism, effects and functions had been summarized. History of the tumor treatment of Chinese yew had been traced back to the time of Tang Dynasty and this was almost 1 200 years earlier than western countries.