ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical feature of early newborn infants with congenital heart disease.</p><p><b>METHODS</b>We retrospectively analyzed the clinical features of 477 newborn infants with congenital heart disease born within seven days out of 28 050 live births in Shaoxing women and children hospital from October 1, 2009 to September 30, 2012. Infants with congenital heart disease were divided into single malformation group (240 cases), composite deformity group (199 cases) and multiple malformations group (38 cases). Differences of clinical feature were compared between the three groups.</p><p><b>RESULTS</b>Atrial septal defect was the most malformation 91.6% (437/477) .Incidence of preterm birth was higher in newborn inants with congenital heart disease [512.23/10 000(134/2 616)] than infants without without congenital heart disease [134.86/10 000 (343/25 434) , P < 0.01]. Proportion of preterm birth among the three congenital heart disease groups was similar (P > 0.05) . The incidence of small for gestational age in congenital heart disease group (10.90%, 52/477) was also significantly higher than those without congenital heart disease group (5.91%, 1 630/27 573, P < 0.01).Small for gestational age with congenital heart disease of complex malformations, multiple malformations groups was higher than that in the single malformation group (P < 0.01 and P < 0.05).</p><p><b>CONCLUSIONS</b>Early newborn with atrial septal defect is the most common neonatal congenital heart disease. The incidence of preterm is higher in newborn infants with congenital heart disease. Complex and multiple malformations are linked with small for gestational age birth weight.</p>