ABSTRACT
Background: Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used in clinical practice. As the progress of endoscopic techniques, NSAIDs-induced small intestinal injury is more frequently to be detected, but there is still lack of effective preventive and therapeutic measures. Aims: To explore the role of regulatory T cells (Treg cells)/Th17 cells imbalance in NSAIDs-induced small intestinal injury and the protective effect of angiotensin 1-7[Ang(1-7)]. Methods: Thirty male Sprague-Dawley rats were randomly divided into control group, model group, and Ang(1-7) treatment group; in the latter two groups, diclofenac sodium was used to induce small intestinal injury. On day 5, the rats were sacrificed to obtain small intestinal mucosa. The macro- and microscopic changes of the intestinal mucosa were evaluated; the levels of Ang(1-7), and pro- and antiinflammatory cytokines were detected by ELISA and/or immunohistochemistry; flow cytometry was used to determine the proportions of Treg and Th17 cells in CD4
ABSTRACT
Hemorrhagic fever with renal syndrome (HFRS) is caused by a hantavirus genus virus,and it is a serious harmful natural foci disease.In recent years,studies show that compared with previous reported patients,HFRS has some changes,such as lack of typical "three red,three pain".Clinical manifestations are varied,and the disease is easily to be misdiagnosed and wrong treated.The clinical research of this disease is summarized in this paper.
ABSTRACT
Hemorrhagic fever with renal syndrome (HFRS) is caused by a hantavirus genus virus,and it is a serious harmful natural foci disease.In recent years,studies show that compared with previous reported patients,HFRS has some changes,such as lack of typical "three red,three pain".Clinical manifestations are varied,and the disease is easily to be misdiagnosed and wrong treated.The clinical research of this disease is summarized in this paper.