ABSTRACT
Objective To study the effect of Mycoplasma pneumoniae infection on the coagulation system in children and to clarify its mechanism in order to guide the therapeutic strategy for Mycoplasma pneumoniae infection in clinical practice.Methods A prospective and case control study was carried out in 36 children with Mycoplasma pneumoniae infection in Weifang People ' s Hospital from January through December in 2011.The 36 patients were divided into two groups according to the MP-IgM plasma titers,namely low-titer group with MP-IgM 1 ∶ 80-1 ∶ 160 (n =17) and high-titer group with MP-IgM 1 ∶ 320-1 ∶1280 (n =19).The subjects of control group (n =20) were recruited from healthy children as they took routine physical examination during the same period.Six indexes related to the coagulation function as well as D-dimer in plasma were determined.All data were analyzed by using SPSS 15.0 software.Results The levels of fibrinogen (FIB) and D-dimer in the low-titer group and high-titer group were significantly higher than those in the control group (P ＜ 0.05).The prothrombin (PT) and activated partial thromboplastin time (APTT) in the high-titer group were significantly shorter than those in the control group respectively (P ＜ 0.05).Conclusions Mycoplasma pneumoniae infection in children gives rise to the potential for activating the extrinsic and intrinsic coagulation system,promoting thrombosis and in turn inducing ischemic stroke in serious cases.
ABSTRACT
OBJECTIVE To analyze the distribution,risk factors and preventive measures of nosocomial infection in patients with hemodialysis. METHODS Clinical data of 112 patients with hemodialysis were retrospectively reviewed.Statistic analysis was made on relation between the occurrence of nosocomial infection and patients′ age,adequacy of dialysis,dialysis duration,anemia,heart function,serum albumin,catheterization and reused dialyzer. RESULTS 67 infection cases were found.The main infection sites were blood vessel access,respiratory tract,and urinary tract.The infection rates increased significantly in the groups of age 60,inadequate dialysis,dialysis duration more than 1 year,serum albumin,heart failure and hypoalbuminemia compared with the correspondent controly group(P 0.05). CONCLUSIONS Patients with hemodialysis have higher infection rates,the main risk factors are old age,inadequate dialysis,long dialysis duration,severe anemia,heart failure,catheterization and hypoalbuminemia.Therefore the effective measures to reduce the nosocomial infection are strictly aseptic technology,adequate dialyzsis,reducing the invasive operation,ameliorating anemia and improving the nutrition.