ABSTRACT
OBJECTIVE To investigate the antibiotic resistance and nosocomial infections status of Staphylococcus aureus (SAU) and provide scientific evidence for diseasis diagnose and reasonable use of antibiotics. METHODS A retrospective review was performed to analyze the clinical distribution of 321 isolates of SAU. Antibiotic susceptibility test was performed by K-B method and drug-resistance results were analyzed. RESULTS SAU was found been resistant to the diverse antibiotics in different degree. However, the drug sensitivity rate to glycopeptide antibiotics was 100.0%, as well as to new type antibiotic of linezolid. The isolating rate of meticillin-resistant S. aureus (MRSA) reached 57.6%. CONCLUSIONS S. aureus shows multidrug resistance to the commonly used antibiotics. We should strengthen monitoring and controlling of it.
ABSTRACT
OBJECTIVE To investigate the distribution and drug-resistance of Pseudomonas aeruginosa(PAE) in nosocomial infections to provide the scientific evidence for the clinical use of the antibiotics.METHODS PAE was cultured and identified according to the National Rules of Procedures Clinical Laboratory.Drug resistance was analyzed by K-B methods.RESULTS A total of 318 strains of PAE were mainly isolated from intensive care unit(ICU),departments of cerebral surgery and chest surgery.Drug-resistance of PAE to 14 kinds of antibiotics showed that SXT(91.2%),cefotaxime(89.9%),aztreonam(70.1%),gentamicin and ciprofloxacin(69.8%),respectively.And the resistance to piperacillin,levofloxacin and cefepime was 50.0%.CONCLUSIONS Drug-resistance status of P.aeruginosa is very serious.Hospital should strengthen monitoring and controlling of it.
ABSTRACT
OBJECTIVE To investigate drug-resistance status of Klebsiella pneumoniae(KPN) in nosocomial infections and provide the reference for rational application of antibiotics.METHODS According to Nationwide Rules of Clincal Laboratory Manipulation,the strains were identified and drug-sensitivity test was performed by K-B methods.The extended-spectrum-?-lactamases(ESBLs) producing strains were detected by double-disc synergy test and disc confirmed test.RESULTS Totally 356 strains of KPN were mainly isolated from respiratory department,gerontology department,neurosurgery department and chest surgery department.The specimens were mostly sputum,pharynx swab,urine and secretion.The detection rate of ESBLs-producing KPN was 36.0%.The drug-resistance rate to common antibiotics in ESBLs producers was generally higher than that in ESBLs nonproducers.No KPN was resistant to imipenem and meropenem.CONCLUSIONS Drug-resistance status of K.pneumoniae in nosocomial infections is very serious.We should strengthen monitoring and controlling of it.