ABSTRACT
High fluoride exposure induces not only skeletal damage such as dental fluorosis and skeletal fluorosis, but also injury on the cardiovascular system. In this article, we elaborated on the effects of high fluoride exposure on cardiovascular diseases such as heart injury, vascular sclerosis, hypertension and hyperlipidemia by reviewing domestic and foreign literatures in the last decade. We analyzed the damage effects and mechanisms of high fluoride exposure from the perspectives of population epidemiology, animal experiments and in vitro cell experiments, and proposed that prospective cohort studies on the effects of high fluoride exposure on cardiovascular system damage should be further strengthened. This paper provides a scientific basis and new ideas for the prevention and treatment of endemic fluorosis and cardiovascular diseases.
ABSTRACT
Objective To explore the relationship between fluoride exposure levels and thyroid structure and function in school-age children, and to provide epidemiological evidence for the prevention and treatment of thyroid diseases and for the control of high fluoride hazards. Methods In 2019, 217 children aged 8-10 years were selected from 3 primary schools in the historical high fluoride area of Tianjin. Basic information was collected by questionnaire surveys. Urine and blood samples were collected for the determination of urine iodine, urine fluoride, and thyroid hormone as well as antibodies. The dental fluorosis was examined by Dean’s method and the thyroid structure was examined by ultrasound. Results There was no significant difference in gender, age and BMI of children with different urine fluoride levels (P>0.05). There was significant difference in the degree of dental fluorosis among children with different urine fluoride levels（χ2=16.263, P=0.012）, and the prevalence of dental fluorosis was higher in children with higher urine fluorine level. There was no significant difference in goiter, nodule, hypothyroidism, hypothyroidism and antibody double positive distribution among children with different urine fluoride levels (P>0.05), but the distribution of TGAb+ or TPOAb+ showed significant difference (χ2=8.697，P=0.034). Logistic analysis showed that there was no correlation between urinary fluoride level and antibody single positive (P>0.05). Conclusion Compared with children with low fluoride exposure levels, children with high fluoride exposure have higher antibody single positive rate, but comprehensive analysis do not find a positive correlation between urinary fluoride level and thyroid structure and disease.
ABSTRACT
Objective To comprehensively evaluate the health education effects of iodine deficiency disorders in different areas of Tianjin, and to provide a reference for improving the quality of iodine deficiency disorders health education. Methods The rank sum ratio method (RSR), TOPSIS and fuzzy combination were used to comprehensively evaluate the effect of health education intervention on iodine deficiency disorders in 16 areas of Tianjin. Results The evaluation results of RSR, TOPSIS and fuzzy combination method ranked N, D, and E areas in the last three places, while G, F, and P areas ranked first, second, and third. Combined with the RSR method, it was shown that in the evaluation of the effects of iodine deficiency health education interventions in 16 areas, the health education effect in G, F and P areas was classified as superior, the health education effect in D ,E and N areas was classified as inferior, and other areas were moderate. Conclusion The fuzzy combined RSR-TOPSIS method avoided the limitation of using either RSR or TOPSIS alone and made the conclusion more objective and accurate, and provided comprehensive quantitative results for the health education of iodine deficiency diseases in different areas of Tianjin. This fuzzy combination method objectively evaluated the intervention effect of health education in different areas, which provides a reference for improving the quality of health education for iodine deficiency disorders.
ABSTRACT
Objective Apolipoprotein E(ApoE) gene polymorphism and alzheimer and coronary heart disease was studied ,and the correlation between them was evaluated.Methods The polymerase chain reaction-restriction fragment length polymorphism was used to amply 227 base-pari DNA fragment in the fourth exon of ApoE gene,and digested them with restriction enzyme CfoI,electrophoresis on 8% polyacrylamaid gel for the cleavaged products,subsequently genotype was determined by silver staining and allele frequencies were counted.Results apoE genotype and allele frequencies was detected in 33 case with Alzheimer and 37 case with coronary heart disease.The results showed that the frequencies of ApoE ? 4 was significantly higher than that in age-matched controls(P