Some clinical and laboratory features of HIV/AIDS infected persons in Ha Noi City

The study was carried out in Ha Noi City from 1996 to January 2001 and involved 126 patients who were positive to HIV1. The results showed that HIV infection is most common in persons who are between 16 to 30 years old (77.78%). Among these, males are 94.45% and females are 5.55%. Drug injected users account for 70.63%. 4.76% of these persons have infection through sex relationship with prostitutors, 2.38% have infection via sex relationship with husband/wife. 98 out of 126 patients have clinical symptoms. The common symptoms are large lymphatic node, fever, cough, dermatitis, diarrhea and weight loss. There was decrease in RBC and hematocrite. Immunosuppressive condition results in opportunity infections, in which tuberculosis is commonest. Chest X-ray should be performed early to detect this condition.

Concentration of tumor necrosis factor-alpha (TNF-alpha) in the acute hepatitis B

19 patients (male: 17) with ages of 16-56 in the Institute of Clinical Medicine and Tropical Diseases participated to a study whose blood samples were measured the concentration of tumor necrosis factor - alpha (TNF-alpha), biochemical and hematological, immunological parameters. The results have shown that there was a high increase of TNF-alpha in patients with acute hepatitis B comparing with this in normal people. There was a correlation between the TNF-alpha and SGOT within the first 2-3 months of disease. There was a correlation between TNF-alpha and SGPT in the second months of disease. There was indirect proportional between the TNF-alpha and serum total bilirubine in the second months of disease.

Circulate immunal complex and its relation with hepatic functional tests in the acute hepatitis B

Hepatitis B is a common disease in Vietnam; 15-20% of population carries HbsAg. The investigation of etiology and prognosis should consider the circulate immunal complex (CIC). A study on 65 patients with ages of 17-60 in the Institute of Clinical Medicine and Tropical Diseases during 1997-1998 has shown that the CIC in patients with acute hepatitis B was significantly increased comparing with this normal people. 63% of patients with acute hepatitis B experienced the increase of CIC 250. There was a relation between CIC and some hepatic functional tests in the same time.

Changes of the amount and rate of lymphocyte T in patients with acute or chronic hepatitis B and cirrhosis

A study on 105 patients in the Institute of Clinical Medicine and Tropical Diseases from 12/1997-1/1999 has shown that the lymphocyte TCD 3, TCD4 and TCD8 increased in patients with acute hepatitis B, these cells remained at normal level in patients with the chronic hepatitis B, there was an increase of lymphocyte TCD4 in patients with cirrhosis. The amount of lymphocyte was significantly reduced. The lymphocyte T in the patients with acute hepatitis B was higher than these in patients with chronic hepatitis B.

The determination of ALPHA FOETO PROTEIN (AFP) and the correlation of AFP with hepatic functional tests in acute hepatitis B

An investigation were carried out on 42 patients of acute hepatitis B (male: 34; female: 8; age: 17-50) at Institute of Clinical Medicine and Tropical Diseases from May to Dec, 1997. Hematology biochemistry tests are determined. The results: the increased concentration of AFP in serum of acute hepatitis B patients (87,95 +/_ 12,89 ng/ml) in compared with normal person. The high level of AFP of 10ng/ml on 20/42 patients (47, 6%). There is a correlation of AFP level, transaminase with AST in the phases I and III and ALT in the phases III. AFP correlates with bilirubin TP during acute hepatitis.

Clinical and paraclinical feature of mumps with testitis

A study on 97 patients with mumps and testitis in the Institute of Clinical medicine and Tropical Diseases during 2001-2002 has shown that ages of 10-50, fever pain in the jaw angle, nodes in the jaw angle, parotitis, testitis. Symptoms when occuring testitis: returned high fevers, swollen and pain in the testis, red in scrotum skin, paraclinical features included leucocyte

Determination of DNA of hepatitis B virus in the serum by PCR

31 samples of sera from patients with hepatitis B or chronic hepatitis in Japan, were divided into 3 groups according to the status of HBsAg and HBeAg and implemented the PCR. The results have shown that PCR was more sensitive and specific than DNA diagnosis. The PCR can detect serum HBV DNA in the almost of patients with HBeAg (+). The serum samples with low efficacy of HBeAg or nagative HBeAg and negative HBVDNA showed the normal level of ALT at the same time.